Unknown: Unusual exophytic nodule on the plantar foot

Kaposi sarcoma (KS) may be categorized into four primary clinical variants: classic, iatrogenic, endemic or African, and epidemic or acquired immunodeficiency syndrome (AIDS)-related KS. Acquired immunodeficiency syndrome-associated Kaposi sarcoma typically presents on the face and trunk as pink to red macules and papules and can be rapidly progressive leading to disseminated visceral involvement and death. Rarely has AIDS-associated KS been described as presenting on the feet. We report a case of AIDS-associated nodular KS manifesting as an exophytic nodule on the plantar foot.