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Related Concept Videos

Serum Studies: Renal Function Tests01:24

Serum Studies: Renal Function Tests

Renal function tests are crucial for assessing kidney health, monitoring disease progression, and evaluating the kidneys' efficiency in waste elimination, fluid balance, and electrolyte regulation. These tests offer critical insights into kidney function, even though routine measurements may appear normal until there is a significant decline in the glomerular filtration rate or GFR. Typically, signs of kidney impairment only become evident when the GFR falls to about 50% of its normal level.
Roles of Electrolytes: Calcium and Phosphate01:27

Roles of Electrolytes: Calcium and Phosphate

Calcium and phosphate are essential electrolytes in the human body, with calcium being the most abundant mineral. Around 99% of the body's calcium is stored in the skeleton and teeth, forming a crystal lattice of mineral salts in combination with phosphates. Calcium plays crucial roles in various bodily functions such as blood clotting, neurotransmitter release, muscle tone maintenance, and nervous and muscle tissue excitability.
The calcium concentration in blood plasma is primarily regulated...
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess the...
Phosphate Buffer01:22

Phosphate Buffer

The phosphate buffer system is a critical biological mechanism for maintaining pH stability in the body. This system operates primarily through two components: sodium dihydrogen phosphate (NaH2PO4), which acts as a weak acid, and sodium hydrogen phosphate (Na2HPO4), which serves as a weak base.
Sodium dihydrogen phosphate does not fully dissociate in neutral or acidic solutions. When a strong base, such as sodium hydroxide (NaOH), is introduced into the solution, sodium dihydrogen phosphate...
Burn Injuries01:22

Burn Injuries

Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Introduction to Electrolytes01:33

Introduction to Electrolytes

In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
Role of Sodium
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Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
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Serum phosphate level in burn patients.

Shahriar Loghmani1, Mohammad Reza Maracy, Reza Kheirmand

  • 1Department of Plastic Surgery, Imam Musa-Kazem Burn Hospital, Isfahan University of Medical Sciences, Kaveh Street, Isfahan, Iran. sh_loghmani@yahoo.com

Burns : Journal of the International Society for Burn Injuries
|April 23, 2010
PubMed
Summary

Hypophosphatemia is common in burn patients, increasing with burn severity. Routine phosphate monitoring after major burns is recommended for timely intervention.

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Assaying for Inorganic Polyphosphate in Bacteria
07:20

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Published on: January 21, 2019

Area of Science:

  • Burn Care
  • Clinical Chemistry
  • Critical Care Medicine

Background:

  • Plasma phosphate imbalance is rare but common in burn patients, potentially caused by the burn or its treatment.
  • Severe hypophosphatemia (<1.0 mg/dL) is linked to increased morbidity and mortality.
  • This study investigates the relationship between serum phosphate levels and burn severity (Total Body Surface Area - TBSA).

Purpose of the Study:

  • To compare serum phosphate levels with varying percentages of TBSA burns.
  • To determine the incidence of hypophosphatemia in relation to burn size.
  • To establish the correlation between burn severity and phosphate imbalance.

Main Methods:

  • 155 burn patients were categorized into three groups based on TBSA: 20-29% (Group A), 30-39% (Group B), and >40% (Group C).
  • Analysis of Variance (ANOVA)-repeated measure was used to analyze serum phosphate levels at 3, 6, and 9 days post-burn.
  • Statistical significance was assessed for differences between groups and time points.

Main Results:

  • Hypophosphatemia incidence at day 9 was 6.1% (Group A), 32.4% (Group B), and 73.5% (Group C).
  • Significant differences (p<0.05) in mean serum phosphate levels were observed between all three groups (A vs C, B vs C, A vs B).
  • Statistically significant differences were found across the three post-burn follow-up time points.

Conclusions:

  • Hypophosphatemia (mean serum phosphate <3.0 mg/dL) is highly prevalent after burns, affecting 75.6% of patients with >40% TBSA at day 3.
  • Increasing TBSA percentage significantly correlates with a higher incidence of hypophosphatemia.
  • Routine phosphate level monitoring is advised for major burn patients, particularly those with complex cases, to enable prompt phosphate replacement therapy.