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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Measuring Psoriasis Severity at Home
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Psoriatic arthritis: correlation between imaging and pathology.

Ai Lyn Tan1, Dennis McGonagle

  • 1Section of Musculoskeletal Disease, Leeds Institute of Molecular Medicine, University of Leeds and Chapel Allerton Hospital, Chapeltown Road, Leeds LS7 4SA, United Kingdom. a.l.tan@leeds.ac.uk

Joint Bone Spine
|April 23, 2010
PubMed
Summary

Psoriatic arthritis (PsA) imaging reveals key pathologies like enthesitis. Advanced imaging techniques enhance understanding of PsA

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Area of Science:

  • Rheumatology and Medical Imaging

Background:

  • Psoriatic arthritis (PsA) is a form of spondyloarthritis that can mimic rheumatoid arthritis with polyarthritis.
  • Imaging plays a crucial role in understanding PsA pathophysiology, revealing characteristic changes like "pencil-in-cup" deformities and periostitis.

Purpose of the Study:

  • To explore how various imaging modalities contribute to understanding the pathophysiology of psoriatic arthritis.
  • To highlight the role of advanced imaging in elucidating the relationship between enthesitis, synovitis, and osteitis in PsA.

Main Methods:

  • Review of imaging findings in psoriatic arthritis, including conventional radiography, MRI, and ultrasonography.
  • Correlation of imaging findings with histological studies and clinical presentation.
  • Discussion of advancements in imaging technology and protocols.

Main Results:

  • Conventional radiography shows "pencil-in-cup" deformities and periostitis.
  • MRI and ultrasonography demonstrate the interplay between enthesitis, synovitis (synovio-entheseal complex), and osteitis/bone edema.
  • Histological studies confirm MRI findings in skin and nails.

Conclusions:

  • Imaging is essential for understanding psoriatic arthritis pathophysiology, particularly the role of enthesitis.
  • Advanced imaging techniques like high-resolution MRI and ultrasonography offer deeper insights into disease mechanisms.
  • Early detection of pre-clinical changes via imaging may lead to improved screening and understanding of the skin-joint connection in PsA.