Related Experiment Video

Updated: Jun 13, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Chronic kidney disease and cardiovascular risk

Preethi Yerram1, Poorna R Karuparthi, Laura Hesemann

  • 1Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri, USA.

Journal of the American Society of Hypertension : JASH
|April 23, 2010
PubMed

Insights

Chronic kidney disease (CKD) significantly increases cardiovascular disease (CVD) risk, often due to traditional and uremia-related factors. Microalbuminuria may serve as a key marker for assessing CVD risk in CKD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Public Health

Background:

  • Chronic kidney disease (CKD) is a global health issue.
  • CKD, especially with type 2 diabetes mellitus (T2DM) and hypertension (HTN), accelerates end-stage renal disease (ESRD) and elevates cardiovascular disease (CVD) risk.
  • CVD is the primary cause of premature death in CKD patients, occurring at twice the rate of the general population.

Purpose of the Study:

  • To review the pathophysiology of CVD in CKD.
  • To explore the role of microalbuminuria (MAU)-proteinuria in CVD risk assessment for CKD patients.

Main Methods:

  • Literature review focusing on the interplay of traditional and nontraditional risk factors in CKD-related CVD.
  • Analysis of microalbuminuria (MAU)-proteinuria as a diagnostic and prognostic tool.

Main Results:

  • CVD progression in CKD is influenced by both traditional risk factors and uremia-related nontraditional factors.
  • The complex pathophysiology of CVD in CKD involves an interplay between these factors.
  • Microalbuminuria (MAU)-proteinuria shows potential as a tool for CVD risk stratification in CKD.

Conclusions:

  • CKD patients face a significantly higher risk of CVD morbidity and mortality.
  • Understanding the multifactorial pathophysiology of CVD in CKD is crucial.
  • Microalbuminuria (MAU)-proteinuria warrants further investigation as a prognostic marker for CVD in CKD.

More Related Videos

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of fluid...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Diabetic Nephropathy01:28

Diabetic Nephropathy

Definition Diabetic nephropathy is a chronic kidney complication that results from prolonged hyperglycemia.Prevalence It is the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) worldwide, affecting up to half of individuals with diabetes.Pathophysiology • Sustained hyperglycemia triggers multiple hemodynamic and metabolic changes in the kidney. • Early in the disease, increased renal blood flow and glomerular hyperfiltration occur due to afferent arteriolar...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...