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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Chronic kidney disease and cardiovascular risk
Preethi Yerram1, Poorna R Karuparthi, Laura Hesemann
1Department of Internal Medicine, University of Missouri School of Medicine, Columbia, Missouri, USA.
Journal of the American Society of Hypertension : JASH
|April 23, 2010
Summary
Chronic kidney disease (CKD) significantly increases cardiovascular disease (CVD) risk, often due to traditional and uremia-related factors. Microalbuminuria may serve as a key marker for assessing CVD risk in CKD patients.
Area of Science:
- Nephrology
- Cardiology
- Public Health
Background:
- Chronic kidney disease (CKD) is a global health issue.
- CKD, especially with type 2 diabetes mellitus (T2DM) and hypertension (HTN), accelerates end-stage renal disease (ESRD) and elevates cardiovascular disease (CVD) risk.
- CVD is the primary cause of premature death in CKD patients, occurring at twice the rate of the general population.
Purpose of the Study:
- To review the pathophysiology of CVD in CKD.
- To explore the role of microalbuminuria (MAU)-proteinuria in CVD risk assessment for CKD patients.
Main Methods:
- Literature review focusing on the interplay of traditional and nontraditional risk factors in CKD-related CVD.
- Analysis of microalbuminuria (MAU)-proteinuria as a diagnostic and prognostic tool.
Main Results:
- CVD progression in CKD is influenced by both traditional risk factors and uremia-related nontraditional factors.
- The complex pathophysiology of CVD in CKD involves an interplay between these factors.
- Microalbuminuria (MAU)-proteinuria shows potential as a tool for CVD risk stratification in CKD.
Conclusions:
- CKD patients face a significantly higher risk of CVD morbidity and mortality.
- Understanding the multifactorial pathophysiology of CVD in CKD is crucial.
- Microalbuminuria (MAU)-proteinuria warrants further investigation as a prognostic marker for CVD in CKD.
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