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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

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Related Experiment Video

Updated: Jun 13, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Drug repurposing for drug development in stroke.

Susan C Fagan1

  • 1Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, GA, USA.

Reviews in Neurological Diseases
|April 23, 2010
PubMed
Summary

Repurposing older drugs like candesartan offers a safer, lower-risk strategy for acute stroke treatment. This approach aims to provide vascular protection, avoiding the high costs and failures of developing new stroke therapies.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Cardiovascular Research

Background:

  • Developing novel acute stroke treatments has faced significant challenges, marked by expensive and unsuccessful trials.
  • Drug repurposing presents a viable, lower-risk alternative by utilizing established safe medications.

Purpose of the Study:

  • To explore the potential of repurposing existing drugs for acute stroke treatment.
  • To investigate candesartan as a vascular protective agent in the context of stroke.

Main Methods:

  • Literature review and analysis of existing pharmacological data.
  • Evaluation of candesartan's known mechanisms of action relevant to vascular protection.

Main Results:

  • Candesartan, an angiotensin II receptor blocker, demonstrates potential for vascular protection.

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Last Updated: Jun 13, 2026

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique
07:34

Induction of Acute Ischemic Stroke in Mice Using the Distal Middle Artery Occlusion Technique

Published on: December 15, 2023

  • Drug repurposing minimizes the risks and costs associated with novel drug development for stroke.

    • Conclusions:

    • Repurposing safe, older drugs like candesartan is a promising strategy for acute stroke management.
    • Vascular protection via repurposed medications offers a more feasible path forward compared to novel agent development.