Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Herniated Intervertebral Disc l: Introduction01:29

Herniated Intervertebral Disc l: Introduction

Intervertebral disc herniation refers to the displacement of the nucleus pulposus (the gel-like inner core of the disc) through a tear or weakened area in the annulus fibrosus (the outer fibrous ring). The displaced disc material extends beyond the normal boundaries of the disc space and may compress or irritate nearby spinal nerve roots or, less commonly, the spinal cord.Etiology and Risk FactorsHerniation commonly results from degeneration, in which aging reduces disc hydration and...
Secondary Spinal Cord Injury llI: Pathophysiology01:25

Secondary Spinal Cord Injury llI: Pathophysiology

Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
Spinal Cord Injury ll: Pathophysiology01:14

Spinal Cord Injury ll: Pathophysiology

Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of astrocytic Bmal1 promotes blood-brain barrier disruption and synaptic dysfunction during systemic inflammation.

Journal of neuroinflammation·2026
Same author

Development of New IL-1R Antagonists with Improved Anti-inflammatory Efficacy.

Theranostics·2025
Same author

Surgical treatment of rheumatoid arthritis of the elbow.

Journal of rheumatic diseases·2025
Same author

Type I interferon signaling promotes kainic acid-induced seizures through mTOR activation.

Neuropharmacology·2025
Same author

Author Correction: SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models.

EMBO molecular medicine·2025
Same author

Diverse Clinical Phenotypes of Neuronal Intranuclear Inclusion Disease in South Korea.

Journal of clinical neurology (Seoul, Korea)·2025

Related Experiment Video

Updated: Jun 13, 2026

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

Delayed Post-traumatic Vertebral Collapse: MR Categorization and MR-Pathology Correlation.

Chong Suh Lee1, Je-Wook Yu, Sung Soo Chung

  • 1Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Asian Spine Journal
|April 23, 2010
PubMed
Summary

This study identified four MRI patterns of ischemic vertebral collapse. Understanding these patterns and their histopathologic correlations aids in interpreting spine MRIs for delayed post-traumatic vertebral collapse.

Keywords:
Delayed vertebral collapseMR patternsPathology

More Related Videos

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
06:45

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

Related Experiment Videos

Last Updated: Jun 13, 2026

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device
04:19

Minimally Invasive Treatment for Thoracolumbar Burst Fracture Using Sagittal Alignment Screws and A Trauma Reduction Device

Published on: November 8, 2024

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
06:45

Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity

Published on: September 16, 2022

Area of Science:

  • Radiology
  • Orthopedic Surgery
  • Pathology

Background:

  • Delayed post-traumatic vertebral collapse can present with varied X-ray and MRI findings.
  • Histopathologic evidence of osteonecrosis is often minimal in delayed post-traumatic vertebral collapse biopsies.
  • Understanding MR imaging patterns is crucial for diagnosis.

Purpose of the Study:

  • To categorize the magnetic resonance (MR) appearance of ischemic vertebral collapse.
  • To correlate MR imaging findings with surgical and histologic outcomes.
  • To improve the interpretation of MR images in cases of vertebral collapse.

Main Methods:

  • A retrospective study of 21 patients (22 vertebral bodies) with surgically and histopathologically confirmed ischemic vertebral collapse.
  • MR imaging was performed using a 1.5 T imager with spin echo T1- and T2-weighted sequences in axial and sagittal planes.
  • Consensus evaluation by two experienced musculoskeletal radiologists followed by MR-pathology correlation.

Main Results:

  • Four distinct MR patterns were identified: fluid (14%), compression (41%), granulation (27%), and mixed (18%).
  • Fluid patterns showed hypo-intense T1 and hyper-intense T2 signals, predominantly with bone necrosis.
  • Compression patterns featured decreased anterior column height, with bone necrosis, granulation tissue, marrow fibrosis, and new bone formation.
  • Granulation patterns displayed hypo-intense T1 and intermediate T2 signals, with predominant granulation tissue.

Conclusions:

  • Four characteristic MR imaging patterns of ischemic vertebral collapse are described.
  • Correlation of MR patterns with histopathologic findings enhances diagnostic accuracy.
  • Awareness of these correlations aids in the effective interpretation of clinical spine MR images.