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[Clinical evaluation of cefpirome in children]
Insights
Cefpirome (CPR), a new injectable antibiotic, proved safe and effective for treating acute bacterial infections in children. Clinical evaluation showed positive outcomes in 17 cases, including meningitis, with mild, transient side effects observed in some infants.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Pharmacology
- Antibiotic Therapy
Background:
- Bacterial infections pose significant health risks in children.
- Development of novel antibiotics is crucial for combating resistant pathogens.
- Cephem antibiotics offer a broad spectrum of activity against various bacteria.
Purpose of the Study:
- To evaluate the clinical efficacy and safety of cefpirome (CPR) in pediatric patients.
- To assess the pharmacokinetic profile of CPR in children.
- To determine the tolerability and adverse effects associated with CPR treatment.
Main Methods:
- Clinical trial involving pediatric patients with acute bacterial infections.
- Administration of cefpirome via intravenous injection.
- Monitoring of clinical response, laboratory parameters, and adverse events.
- Pharmacokinetic analysis including plasma half-life and urinary excretion.
Main Results:
- Cefpirome demonstrated effectiveness in all 17 evaluable pediatric cases.
- Successful treatment was observed in a case of purulent meningitis caused by Haemophilus influenzae type b.
- Mild and transient adverse effects, including diarrhea and elevated liver enzymes (GOT, GPT), occurred in two infants.
- The plasma half-life of cefpirome was approximately 1.17 hours, with primary excretion via urine within 6-8 hours in children with normal renal function.
Conclusions:
- Cefpirome is a safe and effective antibiotic for treating susceptible bacterial infections in children.
- The pharmacokinetic profile supports its use in pediatric populations.
- Further studies may explore its role in specific pediatric infectious disease scenarios.
Abstract:
A new injectable cephem antibiotic, cefpirome (CPR), was evaluated clinically in children. CPR was effective in all the 17 evaluable cases with acute bacterial infections including 1 case of purulent meningitis due to Haemophilus influenzae type b. Diarrhea and elevation of serum GOT and GPT were associated with CPR therapy in 2 young infants, although they were mild and transient. The plasma T 1/2 beta of CPR was 1.17 +/- 0.22 hours after bolus injection and mostly excreted in 6 to 8 hours into urine of children with normal renal functions. The data indicate that CPR is safe and effective, when used in children with susceptible bacterial infections.