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[Pharmacokinetics and clinical evaluation of cefpirome in children]
Insights
Cefpirome (CPR) demonstrates favorable pharmacokinetics and clinical efficacy in children, with an 86.7% success rate in treating various infections. This antibiotic showed good safety, with minimal adverse effects observed in pediatric patients.
Area of Science:
- Pediatric Infectious Diseases
- Clinical Pharmacology
- Antimicrobial Therapy
Background:
- Cefpirome (CPR) is a cephalosporin antibiotic.
- Limited data exists on its pediatric pharmacokinetics and clinical outcomes.
Purpose of the Study:
- To evaluate the pharmacokinetics and clinical efficacy of cefpirome in pediatric patients.
- To assess the safety profile of cefpirome in children.
Main Methods:
- Pharmacokinetic analysis of cefpirome in 4 children at doses of 20 mg/kg and 40 mg/kg.
- Clinical efficacy assessment in 15 pediatric cases with bacterial infections.
- Microbiological assessment of bacterial eradication or reduction.
Main Results:
- Mean half-lives of cefpirome were 1.23 ± 0.23 hours and 1.37 ± 0.35 hours for the 20 mg/kg and 40 mg/kg doses, respectively.
- An overall clinical efficacy rate of 86.7% was observed across 15 pediatric cases.
- Six of seven bacterial strains were eradicated, and one was reduced in number; adverse effects were minimal and transient.
Conclusions:
- Cefpirome exhibits favorable pharmacokinetic properties in children.
- Cefpirome demonstrates significant clinical efficacy and a good safety profile for treating pediatric bacterial infections.
Abstract:
Pharmacokinetics and clinical effects of cefpirome (CPR, HR 810) in children were studied. When 20 mg/kg and 40 mg/kg doses of CPR were administered to 4 children through 30 minutes' drip infusion, half-lives were 1.23 +/- 0.23 (mean +/- S.D.) hours and 1.37 +/- 0.35 (mean +/- S.D.) hours, respectively for the 2 dose levels, and recovery rates in urine in the first 6 hours after administration were 74.8% and 56.1%, respectively. CPR was administered to 15 cases (3 tonsillitis, 3 bronchitis, 5 bronchopneumonia, 1 acute cystitis, 1 coxoiliatitis, 1 otitis media, 1 otitis externa). The efficacy rate was 86.7%. Seven strains of bacteria were isolated and identified 4 Haemophilus influenzae, 3 Staphylococcus aureus, 1 Pseudomonas sp. from these cases. These bacteria in children were followed after administration of CPR. Six strains were eradicated and one was reduced in number. No adverse effects of CPR were observed except in 2 cases, one of which showed transient eosinophilia and the other showed a transient increase of transaminase. These results suggest that CPR may be an effective and safe drug to use on children clinically.