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Related Concept Videos

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Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
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Related Experiment Video

Updated: Jun 13, 2026

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
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Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

Severe obstructive sleep apnea elicits concentric left ventricular geometry.

Giovanni Cioffi1, Tiziano Edoardo Russo, Carlo Stefenelli

  • 1Department of Cardiology, Villa Bianca Hospital, Trento, Italy. gcioffi@villabiancatrento.it

Journal of Hypertension
|April 23, 2010
PubMed
Summary

Severe obstructive sleep apnea (OSA) is linked to a higher prevalence of concentric left ventricular (LV) geometry. This finding may help explain the increased cardiovascular event rates observed in patients with moderate/severe OSA.

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Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Related Experiment Videos

Last Updated: Jun 13, 2026

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension
07:38

Comprehensive Echocardiographic Assessment of Right Ventricle Function in a Rat Model of Pulmonary Arterial Hypertension

Published on: January 20, 2023

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Medical Imaging

Background:

  • Obstructive sleep apnea (OSA) negatively impacts cardiac function, potentially leading to left ventricular (LV) hypertrophy.
  • The relationship between OSA severity and LV geometry remains unclear.
  • This study investigated the association between OSA and concentric LV geometry.

Purpose of the Study:

  • To determine if obstructive sleep apnea (OSA) severity is associated with changes in left ventricular (LV) geometry.
  • To test the hypothesis that OSA is related to concentric LV geometry.

Main Methods:

  • 157 patients with suspected OSA underwent echocardiography and 24-h ambulatory blood pressure and ECG monitoring.
  • Patients were categorized into controls, mild OSA, and moderate/severe OSA based on apnea-hypopnea index.
  • Concentric LV geometry was defined by relative wall thickness ≥ 0.43.

Main Results:

  • Moderate/severe OSA patients (n=86) had higher BMI and atrial fibrillation prevalence than mild OSA (n=51) and controls (n=20).
  • Relative wall thickness positively correlated with apnea-hypopnea index (r=0.30, P=0.003).
  • Concentric LV geometry was found in 58% of moderate/severe OSA patients, versus 12% in mild OSA and 20% in controls (P<0.001).

Conclusions:

  • Moderate/severe OSA is significantly associated with a high prevalence of concentric LV geometry.
  • This geometric change may contribute to the elevated cardiovascular event rates in patients with moderate/severe OSA.