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Cell screening using disposable photonic lab on a chip systems.

Bergoi Ibarlucea¹, Elisabet Fernandez-Rosas, Jordi Vila-Planas

¹Centre Nacional de Microelectrònica (IMB-CNM, CSIC), Barcelona, Spain.

Analytical Chemistry

|April 24, 2010

Summary

A novel photonic lab on a chip offers versatile cell screening using scattering and absorption measurements. This low-cost system achieves high sensitivity for cell detection and dead/live cell ratio analysis.

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Area of Science:

Photonics
Biotechnology
Optical Engineering

Background:

Standard flow cytometers are complex and expensive.
Cell screening requires sensitive and efficient detection methods.

Purpose of the Study:

To present a low-cost photonic lab on a chip for versatile cell screening.
To demonstrate its capability for scattering, absorption, and combined measurements.
To analyze optimal wavelengths for sensitivity and limit of detection (LOD).

Main Methods:

Development of a photonic lab on a chip system.
Implementation of three working regimes: scattering, scattering + absorption, and absorption.
Single 30 ms scans for optical property analysis.
Full spectrum acquisition and analysis for wavelength optimization.

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Main Results:

Achieved LODs of 54.9 cells (scattering), 53 cells (scattering + absorption), and 105 cells (absorption) for unlabeled/labeled cells.
Demonstrated dead/live cell ratio measurement with LODs between 7.6% and 6.7%.
Identified optimal working wavelengths for enhanced sensitivity and reduced LOD.

Conclusions:

The photonic lab on a chip provides a low-cost, versatile platform for cell screening.
The system offers high sensitivity and efficient analysis of cell optical properties.
It enables accurate dead/live cell ratio determination for biological research.