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Analysis of Simian Immunodeficiency Virus-specific CD8+ T-cells in Rhesus Macaques by Peptide-MHC-I Tetramer Staining
Published on: December 23, 2016
AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4
Anapatricia García1, Nagadenahalli B Siddappa, Qingsheng Li
1Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. agarci5@emory.edu
Abstract:
A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4(+) T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.
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