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Related Concept Videos

T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
Special Features of Adaptive Immunity01:20

Special Features of Adaptive Immunity

The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...

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Related Experiment Video

Updated: Jun 13, 2026

Expansion and Enrichment of Gamma-Delta (&#947;&#948;) T Cells from Apheresed Human Product
11:51

Expansion and Enrichment of Gamma-Delta (γδ) T Cells from Apheresed Human Product

Published on: September 22, 2021

gammadelta T-cells: basic features and potential role in vasculitis.

Dieter Kabelitz1, Juliane Fazio, Sabine Adam-Klages

  • 1Institute of Immunology, University of Kiel, Kiel, Germany. kabelitz@immunologie.uni-kiel.de

Clinical and Experimental Rheumatology
|April 24, 2010
PubMed
Summary
This summary is machine-generated.

Gamma delta T-cells, a unique immune cell subset, recognize distinct antigens and perform specialized functions. This review explores their potential involvement in vasculitis pathogenesis.

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Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Gammadelta T-cells are a distinct subset of T-lymphocytes with unique antigen recognition capabilities.
  • They exhibit functional plasticity, sharing traits with alphabeta T-cells while also performing specialized roles like IL-17 production and immune regulation.

Purpose of the Study:

  • To explore the potential role of gammadelta T-cells in the pathogenesis of various clinical forms of vasculitis.

Main Methods:

  • Literature review and synthesis of existing research on gammadelta T-cell biology and vasculitis.

Main Results:

  • Gammadelta T-cells possess unique features enabling them to recognize antigens not typically seen by other immune cells.
  • Their functional repertoire includes cytokine production (e.g., IL-17) and regulatory activities, overlapping with specialized alphabeta T-cell subsets.

Conclusions:

  • Gammadelta T-cells represent a promising area of investigation for understanding and potentially treating vasculitis.
  • Further research is warranted to elucidate their specific contributions to different vasculitic conditions.