Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hepatitis C Virus and Type 2 Diabetes: Mechanisms, Clinical Impact, and Post-DAA Management.

Journal of medical virology·2026
Same author

LPS-induced endometrial cell-derived exosomes suppress probiotic Lactobacillus growth.

Scientific reports·2026
Same author

Screening of Medicinal Herbs Identifies <i>Cimicifuga foetida</i> and Its Bioactive Component Caffeic Acid as SARS-CoV-2 Entry Inhibitors.

Viruses·2025
Same author

HERV Modulation in Colorectal Carcinoma Patients: A Snapshot of Endogenous Retroviral Transcriptome.

Journal of medical virology·2025
Same author

Human SLAM-adapted canine distemper virus can enter human peripheral blood mononuclear cells and replicate in mice expressing human SLAM and defective for STAT1 expression.

Virulence·2025
Same author

Production and characterization of single-chain variable fragment antibodies targeting the breast cancer tumor marker nectin-4.

Frontiers in immunology·2024

Related Experiment Video

Updated: Jun 13, 2026

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
09:10

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

Published on: October 28, 2019

Viral interactions with macroautophagy: a double-edged sword.

Liang-Tzung Lin1, Paul W H Dawson, Christopher D Richardson

  • 1Department of Microbiology and Immunology, Dalhousie University, 5850 College St., 7th Floor Sir Charles Tupper Bldg., Halifax, Nova Scotia, Canada B3H 1X5.

Virology
|April 24, 2010
PubMed
Summary

Autophagy, a cellular cleaning process, plays a dual role in viral infections, aiding replication or defense. Understanding this autophagy-virus interplay is crucial for insights into viral pathogenesis and immunity.

More Related Videos

Study of Protein-protein Interactions in Autophagy Research
14:08

Study of Protein-protein Interactions in Autophagy Research

Published on: September 9, 2017

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

Related Experiment Videos

Last Updated: Jun 13, 2026

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
09:10

siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells

Published on: October 28, 2019

Study of Protein-protein Interactions in Autophagy Research
14:08

Study of Protein-protein Interactions in Autophagy Research

Published on: September 9, 2017

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

Area of Science:

  • Cellular Biology
  • Virology
  • Immunology

Background:

  • Autophagy is a fundamental eukaryotic process for degrading cellular components.
  • Viral infections exhibit intricate interactions with the autophagy pathway.
  • These interactions suggest multifaceted roles for autophagy in viral disease.

Purpose of the Study:

  • To review the complex interplay between viruses and the autophagy pathway.
  • To survey current knowledge and emerging themes in this field.
  • To elucidate the virus-specific roles of autophagy.

Main Methods:

  • Literature review of studies on virus-autophagy interactions.
  • Synthesis of current knowledge on autophagy's roles in viral replication.
  • Analysis of autophagy's impact on host immunity and pathogenesis.

Main Results:

  • Autophagy can support viral replication by providing membrane structures.
  • Autophagy influences host immune responses, including innate and adaptive immunity.
  • The pathway affects cell survival, viral pathogenesis, and the clearance of infection.

Conclusions:

  • Autophagy has virus-specific functions in viral replication, immunity, and pathogenesis.
  • Autophagy's dual role impacts both infected and bystander cells.
  • Further research into autophagy-virus interactions is essential for understanding viral diseases.