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Diffusion

Diffusion

Diffusion is a type of passive transport. In passive transport, a substance tends to move from an area of high concentration to an area of low concentration until the concentration is equal across the space. For example, take the diffusion of substances through the air. When someone opens a perfume bottle in a room filled with people, the perfume is at its highest concentration in the bottle and is at its lowest at the edges of the room. The perfume vapor will diffuse, or spread away, from the...

Diffusion

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...

Assessment of Diffusion and Perfusion

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this principle...

Capillary Exchange

Capillary Exchange

The cardiovascular system's chief role is to disseminate gases, nutrients, waste, and other substances to the body's cells. Small molecules like gases, lipids, and lipid-soluble substances directly diffuse through capillary wall endothelial cell membranes. Glucose, amino acids, and ions, including sodium, potassium, calcium, and chloride, use transporters for facilitated diffusion via membrane-specific channels. Glucose, ions, and bigger molecules may also pass through intercellular clefts.

Passive Diffusion: Overview and Kinetics

Passive Diffusion: Overview and Kinetics

Passive diffusion is a critical process that allows small lipophilic drugs to cross the cell membrane along a concentration gradient. This mechanism's efficiency depends on four primary factors: the membrane's surface area, the drug's lipid-water partition coefficient, the concentration gradient, and the membrane's thickness.
When administered orally, drugs establish a substantial concentration gradient between the gastrointestinal (GI) lumen and the bloodstream, expediting their diffusion into...

Protein Diffusion in the Membrane

Protein Diffusion in the Membrane

Proteins show rotational as well as lateral diffusion across the membrane. The lateral diffusion of proteins was confirmed through the cell fusion experiment where mouse and human cells were fused, resulting in hybrid cells. When the human and mouse cells fused, the specific membrane proteins on human and mouse cells were marked with the red and green-fluorescent markers, respectively. Initially, the red and green fluorescence was located on the respective hemisphere of the cell. As time...

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Related Experiment Video

Updated: Jun 13, 2026

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

Published on: December 15, 2014

Diffusion and perfusion of the breast.

Chiara Iacconi¹

¹Breast Unit - Piazza Sacco e Vanzetti, Carrara Hospital (MS), Italy. c.iacconi@med.unipi.it

European Journal of Radiology

|April 24, 2010

Summary

Diffusion-weighted imaging (DWI) and perfusion MRI offer valuable insights into breast lesion cellularity and vascularity. These techniques aid in differentiating benign from malignant tumors and monitoring treatment response.

Area of Science:

Radiology
Oncology
Medical Imaging

Background:

Breast MRI is crucial for diagnosing breast cancer.
Diffusion-weighted imaging (DWI) and perfusion MRI are advanced techniques.
Understanding their clinical applications and limitations is essential.

Purpose of the Study:

To review the current clinical applications of DWI and perfusion breast MRI.
To explain the possibilities and limitations of these imaging techniques.

Main Methods:

Review of published clinical studies on DWI and perfusion breast MRI.
Analysis of DWI for cellularity assessment.
Analysis of perfusion MRI for vascularization assessment.

Main Results:

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A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

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Tracking the Mammary Architectural Features and Detecting Breast Cancer with Magnetic Resonance Diffusion Tensor Imaging

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Published on: December 15, 2014

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment

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A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

A Method for Determination and Simulation of Permeability and Diffusion in a 3D Tissue Model in a Membrane Insert System for Multi-well Plates

Published on: February 23, 2018

DWI provides information on breast lesion cellularity without contrast agents.
DWI assists in distinguishing benign from malignant lesions and monitoring therapy.
Perfusion MRI offers insights into lesion vascularization, aiding characterization and therapy monitoring.

Conclusions:

DWI and perfusion MRI are valuable tools in breast cancer diagnosis and management.
These techniques enhance characterization of breast lesions and assessment of treatment efficacy.