Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of composition dependence in Flory-Huggins parameters on solid dispersion stability prediction.

International journal of pharmaceutics·2026
Same author

Air Pollution and Particulate Matter: Implications in Upper Airway Disease.

International forum of allergy & rhinology·2026
Same authorSame journal

Mathematical modelling of biofilm growth on medical implants incorporating nutrient-dependent phenotypic switching.

Mathematical medicine and biology : a journal of the IMA·2026
Same author

Modelling antibiotic delivery from functionally graded materials to target biofilm-associated infections.

Computers in biology and medicine·2025
Same author

In vitro rifampicin release and antimicrobial activity of biodegradable polymer coatings<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2025
Same author

Correction to "Biomimetic Ginsenoside Rb1 and Probucol Co-Assembled Nanoparticles for Targeted Atherosclerosis Therapy via Inhibition of Oxidative Stress, Inflammation, and Lipid Deposition".

ACS nano·2025

Related Experiment Video

Updated: Jun 13, 2026

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention
11:01

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Published on: September 18, 2015

Modelling drug-eluting stents.

Sean McGinty1, Sean McKee, Roger M Wadsworth

  • 1Department of Mathematics and Statistics, University of Strathclyde, 26 Richmond Street, Glasgow G1 1XH, UK. rs.smcg@maths.strath.ac.uk

Mathematical Medicine and Biology : a Journal of the IMA
|April 24, 2010
PubMed
Summary

Mathematical models simulate drug elution from polymer-coated stents into arterial walls. Findings reveal factors influencing drug delivery, deposition, and cellular concentrations, aiding stent design.

More Related Videos

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180&#176; Curved Artery Test Section
11:00

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Published on: July 19, 2016

Related Experiment Videos

Last Updated: Jun 13, 2026

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention
11:01

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Published on: September 18, 2015

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180&#176; Curved Artery Test Section
11:00

Experimental Investigation of Secondary Flow Structures Downstream of a Model Type IV Stent Failure in a 180° Curved Artery Test Section

Published on: July 19, 2016

Area of Science:

  • Biomedical Engineering
  • Pharmacokinetics
  • Computational Biology

Background:

  • Drug-eluting stents are crucial for preventing arterial restenosis.
  • Accurate modeling of drug release and transport is essential for optimizing stent efficacy.
  • Understanding drug interaction with arterial tissues is key to minimizing side effects.

Purpose of the Study:

  • To develop and analyze mathematical models for drug elution from polymer-coated stents.
  • To investigate the influence of various physiological factors on drug delivery and deposition.
  • To explore methods for modulating drug release rates and their impact on cellular concentrations.

Main Methods:

  • Development of a multi-layered mathematical model encompassing stent polymer, arterial layers (media, adventitia), and plaque.
  • Inclusion of transmural convection, diffusion, and drug-dependent parameters in the model.
  • Simulation of drug elution dynamics under varying release rates and physiological conditions.

Main Results:

  • Transmural convection and diffusion significantly impact drug delivery and deposition patterns.
  • Drug-dependent parameters play a critical role in the elution process.
  • Altering stent release rates directly affects drug concentrations within arterial cells.

Conclusions:

  • Mathematical modeling provides valuable insights into drug elution from coated stents.
  • Optimizing drug release kinetics is crucial for achieving desired therapeutic effects.
  • The models can guide the design of next-generation drug-eluting stents for improved patient outcomes.