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Updated: Jun 13, 2026

Identifying the Effects of BRCA1 Mutations on Homologous Recombination using Cells that Express Endogenous Wild-type BRCA1
Published on: February 17, 2011
A BRCA1 promoter variant (rs11655505) and breast cancer risk
Paolo Verderio1, Sara Pizzamiglio, Melissa C Southey
1Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. paolo.radice@istitutotumori.mi.it
Background:
A study of Chinese women recently suggested that the minor allele of rs11655505 in the BRCA1 promoter (c.-2265C-->T) increases promoter activity and has a protective effect on breast cancer risk.
Methods:
We genotyped rs11655505 in 2912 female breast cancer cases and 2783 unaffected female controls from four Caucasian breast cancer studies.
Results:
No evidence for an association between rs11655505 and breast cancer risk was found.
Conclusions:
Our study failed to confirm a role of rs11655505 in breast cancer risk. Larger studies are necessary to determine if there is a weak association between this SNP and breast cancer risk.
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