Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
What are Lipids?01:38

What are Lipids?

Overview
What are Lipids?01:31

What are Lipids?

Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and carbon-hydrogen bonds...
What are Lipids?01:31

What are Lipids?

Lipids function as structural components of cellular membranes, in addition to acting as energy reservoirs and signaling molecules. They are thus crucial to all living organisms.  The three biologically important classes of lipids are triglycerides, phospholipids, and steroids.
Non-Polar and Hydrophobic Characteristics of Lipids
Lipids are a structurally and functionally diverse group of hydrocarbons—compounds consisting of carbon and hydrogen atoms. The carbon-carbon and carbon-hydrogen bonds...
What are Lipids?01:38

What are Lipids?

Overview
Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists01:30

Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists

Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function. They...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cannabidiol improves learning and memory deficits and alleviates anxiety in 12-month-old SAMP8 mice.

PloS one·2025
Same author

Global consensus on optimal exercise recommendations for enhancing healthy longevity in older adults (ICFSR).

The journal of nutrition, health & aging·2025
Same author

Gut microbiota disturbances in hospitalized older adults with malnutrition and clinical outcomes.

Nutrition (Burbank, Los Angeles County, Calif.)·2024
Same author

Antisense oligonucleotides targeting the miR-29b binding site in the GRN mRNA increase progranulin translation.

The Journal of biological chemistry·2023
Same author

Low circulating adropin levels in late-middle aged African Americans with poor cognitive performance.

npj aging·2023
Same author

Anorexia of aging: An international assessment of healthcare providers' knowledge and practice gaps.

Journal of cachexia, sarcopenia and muscle·2023

Related Experiment Video

Updated: Jun 13, 2026

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Lipids and cognition.

John E Morley1, William A Banks

  • 1GRECC, VA Medical Center and Saint Louis University School of Medicine, St. Louis, MO, USA.

Journal of Alzheimer'S Disease : JAD
|April 24, 2010
PubMed
Summary
This summary is machine-generated.

Lipids like cholesterol, omega-3 fatty acids (docosahexaenoic acid or DHA), and triglycerides impact cognition in Alzheimer's disease, the elderly, and obesity. While cholesterol's role is debated, DHA and triglyceride levels show clearer links to cognitive function.

More Related Videos

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
09:00

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Published on: July 14, 2022

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Related Experiment Videos

Last Updated: Jun 13, 2026

Lipidomics and Transcriptomics in Neurological Diseases
09:58

Lipidomics and Transcriptomics in Neurological Diseases

Published on: March 18, 2022

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging
09:00

Sample Preparation for Rapid Lipid Analysis in Drosophila Brain Using Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging

Published on: July 14, 2022

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
09:15

Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles

Published on: November 10, 2017

Area of Science:

  • Neuroscience
  • Biochemistry
  • Gerontology

Background:

  • Cholesterol, omega-3 fatty acids, and triglycerides are implicated in cognitive function across Alzheimer's disease (AD), aging, and obesity.
  • Evidence suggests cholesterol influences amyloid-beta (Abeta) regulation and AD pathogenesis, though statin trials show no direct cognitive benefit.
  • Docosahexaenoic acid (DHA) and triglyceride levels are linked to cognitive performance and impairments.

Purpose of the Study:

  • To review the roles of cholesterol, omega-3 fatty acids, and triglycerides in cognitive function.
  • To explore the mechanisms by which these lipids affect cognition in AD, the elderly, and obesity.
  • To synthesize findings from animal, human epidemiological, and in vitro studies.

Main Methods:

  • Review of existing literature including animal studies, human epidemiological data, and in vitro research.
  • Analysis of studies on cholesterol's effect on Abeta and AD pathogenesis.
  • Examination of research on DHA's impact on cognition and lipid peroxidation.
  • Investigation of the relationship between obesity, triglycerides, and cognitive impairments.

Main Results:

  • Cholesterol's direct impact on cognition is uncertain, possibly indirect or spurious.
  • Docosahexaenoic acid (DHA) administration improves cognition and reduces lipid peroxidation in animal models, and is linked to cognitive benefits in humans.
  • Obesity is associated with cognitive deficits, and lowering triglycerides can improve cognition.
  • Triglyceride administration in mice impairs learning and memory.

Conclusions:

  • Lipids significantly influence cognitive function in Alzheimer's disease, the elderly, and obesity.
  • Docosahexaenoic acid (DHA) shows promise for cognitive enhancement.
  • The precise mechanisms linking lipids to cognition require further elucidation.