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Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Antibody Structure01:10

Antibody Structure

Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...

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Updated: Jun 13, 2026

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy
10:39

Advanced Imaging of Lung Homing Human Lymphocytes in an Experimental In Vivo Model of Allergic Inflammation Based on Light-sheet Microscopy

Published on: April 16, 2019

IL-1 and Allergy.

Aya Nambu1, Susumu Nakae

  • 1Atopy Research Center, Juntendo University, Tokyo, Japan.

Allergology International : Official Journal of the Japanese Society of Allergology
|April 24, 2010
PubMed
Summary
This summary is machine-generated.

Interleukin-1 (IL-1), a proinflammatory cytokine, plays a key role in host defense and autoimmune conditions. Studies using gene-deficient mice reveal IL-1

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Area of Science:

  • Immunology
  • Cytokine Biology
  • Autoimmune Disease Research

Background:

  • Interleukin-1 (IL-1) is a critical proinflammatory cytokine.
  • IL-1 is implicated in host defense mechanisms and the development of autoimmune diseases.
  • IL-1 influences the activation of various immune cells, including T helper subsets (Th1, Th2, Th17) and B cells.

Purpose of the Study:

  • To review and discuss the specific role of IL-1 in the pathogenesis of allergic diseases.
  • To explore the contribution of IL-1 to T-cell-mediated disease development.
  • To synthesize findings from studies utilizing IL-1-related gene-deficient mouse models.

Main Methods:

  • Literature review of studies involving IL-1.
  • Analysis of research utilizing gene-deficient mouse models for IL-1 and related genes.
  • Discussion of the immunological pathways influenced by IL-1 in disease contexts.

Main Results:

  • IL-1 promotes the activation of diverse T cell populations (Th1, Th2, Th17) and B cells.
  • Evidence suggests IL-1's involvement in the development of various T-cell-mediated diseases.
  • Studies using gene-deficient mice provide insights into IL-1's specific contributions to disease pathogenesis.

Conclusions:

  • IL-1 is a significant factor in the pathogenesis of allergic diseases.
  • The cytokine's role extends to various T-cell-mediated conditions.
  • Further research using genetic models is crucial for understanding IL-1's complex functions.