Related Experiment Video
Updated: Jun 13, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
Published on: June 15, 2011
Replication study of association between ADCYAP1 gene polymorphisms and schizophrenia
Minori Koga1, Hiroki Ishiguro, Yasue Horiuchi
1Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Genetic variations in the ADCYAP1 gene, including Asp54Gly, were investigated for schizophrenia risk. This study found no significant association, suggesting ADCYAP1 is unlikely to be a major factor in schizophrenia susceptibility.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- The adenylate cyclase-activating polypeptide 1 (ADCYAP1) gene encodes a neuropeptide involved in neurotransmission.
- Previous studies suggested potential associations between ADCYAP1 polymorphisms (rs1893154 and rs2856966/Asp54Gly) and schizophrenia in Japan.
Purpose of the Study:
- To validate the association of ADCYAP1 gene polymorphisms with schizophrenia in a larger Japanese cohort.
- To investigate the role of rs1893154 and rs2856966 (Asp54Gly) in the genetic susceptibility to schizophrenia.
Main Methods:
- A case-control study involving 2027 Japanese schizophrenia patients and 2058 controls.
- Genotyping of ADCYAP1 polymorphisms rs1893154 and rs2856966.
- Statistical analysis including allelic association tests and meta-analysis with prior data.
Main Results:
- No significant allelic association was detected for rs1893154 with schizophrenia (P=0.36).
- rs2856966 showed nominal significance (P=0.045) but in the opposite direction to previous findings.
- Combined meta-analysis of nearly 6000 individuals did not reveal significant associations (P=0.53–0.86).
Conclusions:
- Single-nucleotide polymorphisms within the ADCYAP1 gene, including Asp54Gly, are unlikely to contribute significantly to schizophrenia susceptibility.
- The findings do not support a substantial role for ADCYAP1 in the genetic basis of schizophrenia.
More Related Videos
09:38Generalized Psychophysiological Interaction (PPI) Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
04:41Mapping Alzheimer's Disease Variants to Their Target Genes Using Computational Analysis of Chromatin Configuration
Published on: January 9, 2020
Related Concept Videos
Genome-wide Association Studies-GWAS
GWAS does not require the identification of the target gene involved in...
Biological Causes of Schizophrenia
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Human Genetics
The complex relationship between genetics and psychology is observable through common biological components such...
Comparing Copy Number Variations and SNPs
Copy number variations or CNVs are the structural variations that cover more than 1kb of DNA sequence. The single nucleotide polymorphism (SNP), on the other hand, is a single nucleotide change or a point mutation that is found in more than 1%...
Single Nucleotide Polymorphisms-SNPs
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase