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Laboratory Scale Production and Purification of a Therapeutic Antibody
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Laboratory Scale Production and Purification of a Therapeutic Antibody

Published on: January 24, 2017

Strategies and challenges for the next generation of therapeutic antibodies

Alain Beck1, Thierry Wurch, Christian Bailly

  • 1Centre d'Immunologie Pierre Fabre (CIPF), 5 Avenue Napoléon III, F74160, Saint-Julien-en-Genevois, France. alain.beck@pierre-fabre.com

Nature Reviews. Immunology
|April 24, 2010
PubMed

Antibodies and related products are the fastest growing class of therapeutic agents. By analysing the regulatory approvals of IgG-based biotherapeutic agents in the past 10 years, we can gain insights into the successful strategies used by pharmaceutical companies so far to bring innovative drugs to the market. Many challenges will have to be faced in the next decade to bring more efficient and affordable antibody-based drugs to the clinic. Here, we discuss strategies to select the best therapeutic antigen targets, to optimize the structure of IgG antibodies and to design related or new structures with additional functions.

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