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Nuclear receptor transrepression pathways that regulate inflammation in macrophages and T cells
Christopher K Glass1, Kaoru Saijo
1Department of Cellular and Molecular Medicine, University of California, San Diego, 9500 Gilman Drive, GPL Room 217A, La Jolla, California 92093-0651, USA. ckg@ucsd.edu
Nature Reviews. Immunology
|April 24, 2010
Summary
Nuclear receptors control inflammation by altering gene expression in immune cells. These pathways offer new targets for anti-inflammatory drugs.
Area of Science:
- Molecular biology
- Immunology
- Pharmacology
Background:
- Nuclear receptors are ligand-dependent transcription factors regulating gene expression.
- Immunity and inflammation are complex processes influenced by gene regulation.
- Dysregulated inflammation contributes to various diseases.
Purpose of the Study:
- To review recent findings on how nuclear receptors antagonize pro-inflammatory gene expression.
- To elucidate the mechanisms by which nuclear receptors modulate immune cell function.
- To explore the therapeutic potential of targeting these pathways.
Main Methods:
- Review of recent scientific literature.
- Analysis of gene expression regulation in macrophages and T cells.
- Investigation of co-activator and co-repressor dynamics.
Main Results:
- Nuclear receptors employ distinct mechanisms to repress pro-inflammatory gene programs.
- These mechanisms involve altering co-repressor and co-activator turnover or recruitment.
- Regulation occurs in a gene-specific manner within macrophages and T cells.
Conclusions:
- Nuclear receptor-dependent transrepression pathways are crucial for controlling inflammatory responses.
- These pathways regulate the initiation, magnitude, and duration of inflammation.
- Targeting these transrepression pathways presents a promising pharmacological strategy for inflammatory diseases.
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