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Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
Published on: December 11, 2017
[Echocardiographic assessment of cardiac resynchronization therapy: two-year follow-up period]
Viviane Cordeiro Veiga1, Salomón Soriano Ordinola Rojas, Fernando Sérgio Oliva de Souza
1Universidade Estadual de Campinas, São Paulo, SP, Brasil. vcveiga@cardiol.br
Insights
Echocardiography can predict cardiac resynchronization therapy (CRT) success in heart failure patients. Tissue Doppler assessment of intraventricular dyssynchrony after CRT effectively predicts mortality risk.
Area of Science:
- Cardiology
- Medical Imaging
- Heart Failure Management
Background:
- Cardiac resynchronization therapy (CRT) is a key treatment for advanced heart failure (HF).
- Echocardiography is crucial for both selecting patients for CRT and assessing its effectiveness.
- Identifying patients who will benefit most from CRT remains an ongoing clinical challenge.
Purpose of the Study:
- To evaluate the utility of echocardiography in assessing CRT outcomes.
- To analyze echocardiographic changes at 10 days and 2 years post-CRT implantation.
- To correlate echocardiographic findings with patient survival and quality of life.
Main Methods:
- A prospective study involving 20 heart failure patients undergoing CRT.
- Utilized echocardiography, including tissue Doppler, and the Minnesota Living with Heart Failure Questionnaire (MLWHF).
- Assessed patients at baseline, 10 days, and 2 years after biventricular pacemaker implantation.
Main Results:
- A significant improvement in ejection fraction was observed between baseline and 2 years post-CRT.
- Intraventricular dyssynchrony, measured by tissue Doppler, worsened at 10 days post-CRT.
- Higher MLWHF scores were associated with mortality in the study cohort.
Conclusions:
- Tissue Doppler assessment of intraventricular dyssynchrony post-CRT is a reliable predictor of CRT efficacy.
- Echocardiographic parameters, particularly tissue Doppler, can identify patients at higher risk of mortality after CRT.
- This highlights the importance of detailed echocardiographic follow-up for optimizing CRT management.
Background:
The cardiac resynchronization therapy (CRT) is an effective option for patients with advanced heart failure (HF). Clinical, electrocardiographic and echocardiographic criteria have been studied in an attempt to find the patients that will benefit from the CRT, considering that the echocardiogram is the method that is used both in the selection and in the assessment of such therapy.
Objective:
The objective of this work is to analyze the use of echocardiogram to assess the CRT, in a ten-day follow-up period and after two years of evolution.
Methods:
The assessment considered 20 patients subjected to CRT, for a period of two years, 80% of which were male. The Minnesota Living with Heart Failure Questionnaire (MLWHF) was filled out. Patients underwent a six-minute walking test. Then, the two-dimensional echo-Doppler-cardiogram was performed. The initial assessment was repeated ten days after and two year after the implantation of the biventricular pacemaker.
Results:
In two years, 5 patients (25%) died; 4 had cardiomyopathy caused by the Chagas's disease. There was no statistically significant change in the ejection fraction between the pre-operation period and the following ten days, but there was a significant change between the pre-operation period and two years after that, and the ten-day period and two years after that. In the ten-day follow-up period, there was the worsening of the intraventricular dyssynchrony, as evaluated by the tissue Doppler method, and the 'living with heart failure' score was higher in the group of deaths.
Conclusion:
Out of the echocardiographic parameters assessed, only the intraventricular dyssynchrony assessment through the tissue Doppler method, after the procedure, was capable of predict the CRT efficiency with respect to the death rate.
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