When should we expect prenatally damaged human brains to have abnormal neuronal connections?

Abnormal function in prenatally damaged brains may occur as the result of loss of neuronal an/or glial elements, abnormal morphology of neurons, or abnormal and inappropriate connections. By abnormal connection I mean projections from a given nucleus to a nucleus or cortical region in the brain which does not normally receive such a projection. In the present paper it is proposed that focal brain damage, i.e. that damage involving circumscribed regions of the developing brain on one side of the body, is more likely to induce abnormal connections, than diffuse brain damage, affecting most of the brain bilaterally. This proposition is based on the available evidence from animal studies, albeit scanty, and is presented as a working hypothesis for future studies of human congenital brain damage.