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Updated: Jun 13, 2026

Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
Published on: February 21, 2018
Peptoid macrocycles: making the rounds with peptidomimetic oligomers
Barney Yoo1, Sung Bin Y Shin, Mia Lace Huang
1Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003-6688, USA.
Abstract:
Macrocyclic constraints are often employed to rigidify the conformation of flexible oligomeric systems. This approach has recently been used to organize the structure of peptoid oligomers, which are peptidomimetics composed of chemically diverse N-substituted glycine monomer units. In this review, we describe advances in the synthesis and characterization of cyclic peptoids. We evaluate how the installation of covalent constraints between the oligomer termini or side chains has been effective in defining peptoid conformations. We also discuss the potential applications for this promising family of macrocyclic peptidomimetics.
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