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Parechoviruses in children: understanding a new infection

Heli Harvala1, Katja C Wolthers, Peter Simmonds

  • 1Specialist Virology Centre, Royal Infirmary of Edinburgh, Edinburgh, UK. heli.simmonds@hotmail.com

Current Opinion in Infectious Diseases
|April 24, 2010
PubMed

Insights

Human parechovirus type 3 (HPeV3) is increasingly linked to severe neonatal diseases like sepsis, encephalitis, and hepatitis. This emerging virus may have unique cellular tropism, highlighting the need for better HPeV diagnosis in newborns.

Area of Science:

  • Virology
  • Infectious Diseases
  • Neonatology

Background:

  • Human parechoviruses (HPeVs) are common pathogens within the Picornaviridae family, causing diverse illnesses.
  • While 10 HPeV types exist, HPeV type 3 (HPeV3) shows a specific association with severe neonatal disease.

Purpose of the Study:

  • To review disease associations of HPeV types.
  • To explore the epidemiological and biological basis for differing disease outcomes among HPeV types.

Main Methods:

  • Review of existing literature on HPeV infections.
  • Application of molecular diagnostic techniques to identify HPeV associations.

Main Results:

  • Molecular diagnostics link HPeV3 to neonatal sepsis, encephalitis, and hepatitis, unlike other HPeV types.
  • HPeV3 demonstrates recent emergence in human populations and potential differences in cellular receptor usage.

Conclusions:

  • HPeV3 plays a significant role in severe neonatal infections, possibly due to recent emergence or distinct cellular tropism.
  • HPeV infections are under-diagnosed and warrant consideration in neonates presenting with severe illness.
Abstract

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