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Frequent and prolonged shedding of bocavirus in young children attending daycare

Emily T Martin1, Mary P Fairchok, Jane Kuypers

  • 1Center for Clinical and Translational Research, Seattle Children's Research Institute, 1900 Ninth Avenue, Seattle, WA 98101, USA. emily.martin@seattlechildrens.org

The Journal of Infectious Diseases
|April 27, 2010
PubMed

Insights

Human bocavirus (HBoV) shedding can be prolonged in children. While HBoV detection correlated with more severe respiratory illness, it was not definitively linked to symptom onset or specific symptoms in this daycare study.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Respiratory illness epidemiology

Background:

  • Human bocavirus (HBoV) persistence and shedding patterns are not well understood.
  • The association between HBoV detection and the development or resolution of respiratory symptoms requires further investigation.

Purpose of the Study:

  • To investigate HBoV shedding dynamics in children attending daycare.
  • To determine the relationship between HBoV detection and respiratory illness characteristics, including symptom onset, duration, and severity.

Main Methods:

  • Prospective, longitudinal study design.
  • HBoV testing performed on nasal swab samples from 119 children in daycare.
  • Analysis of HBoV detection, viral load, and association with illness parameters.

Main Results:

  • HBoV was detected in 59% of children and 33% of illness episodes.
  • Extended and intermittent shedding observed, with detection up to 75 days.
  • HBoV-positive illnesses were longer and associated with higher healthcare utilization.
  • HBoV was found in asymptomatic children, with no significant difference in prevalence or viral load compared to symptomatic children at enrollment.

Conclusions:

  • HBoV detection was associated with increased respiratory illness severity.
  • Despite this association, HBoV detection was not linked to the presence or specific symptoms of respiratory illness in this cohort.
  • Findings suggest HBoV may play a role in exacerbating illness rather than directly causing specific symptoms.
Abstract

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