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Updated: Jun 13, 2026

Assays for Validating Histone Acetyltransferase Inhibitors
Published on: August 6, 2020
Class I histone deacetylases 1, 2 and 3 are highly expressed in classical Hodgkin's lymphoma
Heiner Adams1, Florian R Fritzsche, Stephan Dirnhofer
1Institute for Pathology, Zurich University Hospital, Schmelzbergstrasse 12, CH-8091 Zurich, Switzerland. heiner.adams@usz.ch
Objective:
HDAC inhibitors (HDI) are anti-neoplastic drugs with preliminary successful clinical applications in Hodgkin's lymphoma (HL). Systematic investigations of HDAC expression in HL, based on histology and immunohistochemistry are yet rare.
Research Design/Methods:
We investigated the expression of HDAC1, 2 and 3 in 283 HL on tissue microarrays.
Main Outcome Measures:
Expression of HDAC isoforms was scored in Hodgkin and Reed-Sternberg cells (HRSC) and background infiltrate and compared with freedom of treatment failure (FTF) in 118 cases, for which all data was available.
Results:
All analyzable HL expressed the HDAC isoforms 2 (n = 194) and 3 (n = 207) in over 50%, mostly 100%, of HRSC and almost all background lymphocytes. HDAC1 was expressed in 169 of 179 analyzable HL in a mean of 82% and in 172 out of 179 analyzable cases in a mean of 83% of infiltrating lymphocytes. HDAC1 of below 75% in HRSC correlated with worse FTF with 16 out of 32 events, compared with 16 out of 82 in cases with over 75% HDAC1-expressing HRSC.
Conclusion:
HDAC isoforms 1, 2 and 3 are highly expressed in HL. In addition, decreased HDAC1 expression is accompanied by worse outcome in HL.
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