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Updated: Jun 13, 2026
The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
RNA interference therapy for glioblastoma
Dongsheng Guo1, Baofeng Wang, Fuxin Han
1Department of Neurosurgery, Huazhong University of Sciences and Technology, Tongji Medical College, Tongji Hospital, Wuhan, China. guodongsheng@yahoo.com
Importance Of The Field:
Despite numerous advances made during the last decade in brain tumor therapy, the prognosis of glioblastoma has not improved and these tumors inevitably recur with no effective treatment. Thus, any new therapeutic strategy to target this most malignant tumor will be of significant benefit. RNAi is a powerful gene silencing method that might be used in combination with other agents to improve the efficacy of glioblastoma treatment.
Areas Covered In This Review:
Recent progress and challenges of pre-clinical and clinical research of RNAi therapy for glioblastoma. The review covers literature from 2003 to 2009.
What The Reader Will Gain:
The principle of RNA interference therapy, three categories of RNAi triggers, different RNAi delivery system and pre-clinical and clinical studies that are currently underway to evaluate the validity of RNAi as a potential therapeutic strategy against glioblastoma are discussed.
Take Home Message:
RNA inference therapy combined with other therapeutics may offer therapeutic potential for glioblastoma multiforme. Further studies are required to develop more efficient and specific delivery systems, select suitable gene targets, optimize treatment dose and administration schedule, evaluate the efficacy of combination treatment strategies, establish a validated clinical response measure system etc.
Insights
RNA interference (RNAi) therapy shows promise for treating glioblastoma, a deadly brain tumor. Combining RNAi with other treatments may improve outcomes, but further research is needed for effective delivery and targeting.
Area of Science:
- Oncology
- Molecular Biology
- Gene Therapy
Background:
- Glioblastoma prognosis remains poor despite advances in brain tumor therapy.
- Recurrent glioblastoma lacks effective treatment options, necessitating novel therapeutic strategies.
- RNA interference (RNAi) offers a powerful gene silencing approach for glioblastoma treatment.
Purpose of the Study:
- To review the progress and challenges in RNAi therapy for glioblastoma.
- To cover pre-clinical and clinical research from 2003 to 2009.
Main Methods:
- Discussion of RNA interference (RNAi) therapy principles.
- Categorization of RNAi triggers and delivery systems.
- Review of pre-clinical and clinical studies evaluating RNAi for glioblastoma.
Main Results:
- RNAi therapy involves specific gene silencing mechanisms.
- Various RNAi triggers and delivery systems are under investigation.
- Current studies assess RNAi's potential as a glioblastoma therapeutic strategy.
Conclusions:
- Combination therapy with RNAi and other agents may benefit glioblastoma patients.
- Development of efficient delivery systems and specific gene targets is crucial.
- Further research is needed to optimize treatment protocols and clinical response measures.
Related Concept Videos
02:15Experimental RNAi
01:23RNA Interference
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...