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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications

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Related Experiment Video

Updated: Jun 13, 2026

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
04:13

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults

Published on: February 8, 2019

The elderly safety imperative and antipsychotic usage.

Lama M Chahine1, Diler Acar, Zeina Chemali

  • 1Department of Neurology, Cleveland Clinic, OH 44195, USA. ChahinL@ccf.org <ChahinL@ccf.org>

Harvard Review of Psychiatry
|April 27, 2010
PubMed
Summary

Antipsychotics offer some benefit for older adults with psychotic symptoms, but require caution due to risks like increased mortality and cardiovascular events, especially in dementia patients. Careful patient selection is key for safe and effective antipsychotic use in the elderly.

Related Experiment Videos

Last Updated: Jun 13, 2026

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults
04:13

Using a Real-Time Locating System to Measure Walking Activity Associated with Wandering Behaviors Among Institutionalized Older Adults

Published on: February 8, 2019

Area of Science:

  • Geriatrics
  • Psychiatry
  • Pharmacology

Background:

  • Behavioral and psychotic symptoms are prevalent in aging populations.
  • Understanding antipsychotic benefits and risks is crucial for older adults.
  • These symptoms can manifest in dementia, schizophrenia, mood disorders, delirium, or delusional disorder.

Purpose of the Study:

  • To review the use of antipsychotics in older adults.
  • To emphasize the risks and side effects associated with antipsychotic use.
  • To focus on dementia patients experiencing behavioral and psychotic symptoms.

Main Methods:

  • Review of existing studies on antipsychotic use in older adults.
  • Analysis of benefits and risks, including mortality and cardiovascular events.
  • Specific focus on patient selection criteria for antipsychotic therapy.

Main Results:

  • Antipsychotics demonstrate mixed but real benefits in carefully selected older patients.
  • Significant risks include increased mortality and cardiovascular/cerebrovascular events.
  • Dementia patients with behavioral and psychotic symptoms require particular attention.

Conclusions:

  • Antipsychotic use in older adults necessitates careful consideration of benefits versus risks.
  • Risk mitigation strategies and careful patient selection are paramount.
  • Further research is needed to optimize antipsychotic therapy in geriatric populations.