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Updated: Jun 13, 2026

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
Implications of head and neck cancer treatment failure in the neck
David R Deschamps1, Horace J Spencer, Mimi S Kokoska
1University of Arkansas, College of Medicine, Little Rock, AR 72205, USA.
Objective:
Study the survival of patients with cervical lymphatic squamous cell carcinoma recurrence.
Study Design:
Review of tumor registry database.
Setting:
Academic health science center.
Subjects And Methods:
Forty-seven isolated neck recurrence patients identified from 224 recurrences from a total of 1291 patients treated between 1998 and 2007. The main outcome measurements were neck lymph nodal recurrence, treatment-specific survival, and overall survival.
Results:
A total of 47 patients had neck recurrence; 10 of the neck recurrence patients (21.3%) had regional disease (N+) at initial presentation. Median survival for patients with neck recurrence was 14.7 months (95% confidence interval [CI] 8.6-18.1 mo), and five-year survival for this group was five percent (95% CI 0%-30%). Neck dissection salvage therapy for neck recurrence resulted in the best survival.
Conclusion:
Neck dissection as a salvage therapy for neck recurrence resulted in the best survival, and there was no survival benefit in terms of whether a patient had a neck dissection or not as his or her initial therapy.
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