Assessment of COPD severity by computed tomography: correlation with lung functional testing
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Updated: Jun 13, 2026

Multi-modal Pulmonary Imaging: Using Complementary Information from CT and Hyperpolarized 129Xe MRI to Evaluate Lung Structure-Function
Published on: April 12, 2024
Sandra Pauls1, Daniel Gulkin, Sebastian Feuerlein
1Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, Ulm, Germany. sandra.pauls@uni-ulm.de <sandra.pauls@uni-ulm.de>
Abstract:
CT scans of 474 patients with suspected chronic obstructive pulmonary disease (COPD) were retrospectively evaluated by automated software. There was a correlation between the total lung capacity (TLC) and the total lung volume (TLV) (r=.675, P<.001), between the TLC and the total emphysema volume (r=.571, P<.001), as well as between the TLC and the emphysema index (r=.532, P<.001), respectively. The correlation between the TLC and the TLV was dependent on the COPD severity according to the Global Initiative for Chronic Obstructive Lung Disease classification (chi(2)=6.3079, P=.043). The TLC allows a prediction of clinical illness severity.
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