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Updated: Jun 13, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
Published on: December 29, 2021
Reverse-engineering transcription control networks
Timothy S Gardner1, Jeremiah J Faith
1Department of Biomedical Engineering, Boston University, 44 Cummington St., Boston, MA 02215, USA.
Abstract:
Microarray technologies, which enable the simultaneous measurement of all RNA transcripts in a cell, have spawned the development of algorithms for reverse-engineering transcription control networks. In this article, we classify the algorithms into two general strategies: physical modeling and influence modeling. We discuss the biological and computational principles underlying each strategy, and provide leading examples of each. We also discuss the practical considerations for developing and applying the various methods.
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