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Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: the InCHIANTI
Marcello Maggio1, Gian Paolo Ceda, Fulvio Lauretani
1Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy. marcellomaggio2001@yahoo.it
Background & Aims:
Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown.
Methods:
Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy.
Results:
Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15) micromol/L and 113.4 (31.2)ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 (β±SE: 43.76±11.2, p=0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 (β±SE: 36.7±12.2, p=0.003). The association was still significant when IL-6 was introduced in the model (β±SE: 40.1±12.0, p=0.0008).
Conclusions:
We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.