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Updated: Jun 13, 2026

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
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Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke

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Stroke location and brain function in an embolic rabbit stroke model.

Aliza T Brown1, Robert D Skinner, Rene Flores

  • 1Department of Radiology, University of Arkansas for Medical Sciences, M1/269, 4301 West Markham Street, Mail Slot 556, Little Rock, AR 72205, USA.

Journal of Vascular and Interventional Radiology : JVIR
|April 27, 2010
PubMed
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This study refines a rabbit stroke model using angiography, finding middle cerebral artery and anterior cerebral artery strokes allow longer survival for therapy studies. Neurologic deficits varied by stroke location, indicating symptoms alone are unreliable indicators.

Area of Science:

  • Neuroscience
  • Vascular Biology
  • Animal Models

Background:

  • Current rabbit stroke models exhibit variability in stroke characteristics.
  • Existing models often rely on symptom-based endpoints, limiting long-term therapeutic studies.
  • Refinement of stroke models is crucial for advancing stroke research.

Purpose of the Study:

  • To refine an angiographic embolic stroke model in rabbits.
  • To correlate localized infarctions with specific neurologic deficits.
  • To establish a rabbit model suitable for long-term stroke therapy studies.

Main Methods:

  • New Zealand White rabbits underwent selective internal carotid artery angiography with single clot injection.
  • Neurologic Assessment Scores (NAS) were recorded on an 11-point scale at 24 hours.

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Last Updated: Jun 13, 2026

Real-Time Monitoring and Modulation of Blood Pressure in a Rabbit Model of Ischemic Stroke
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Published on: February 10, 2023

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Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

  • Brains were analyzed post-mortem to correlate stroke location and volume with NAS.

    • Main Results:

    • The middle cerebral artery (52%) and anterior cerebral artery (29%) were the most common stroke locations.
    • Strokes in the brainstem and cerebellum produced disproportionately severe neurologic deficits compared to cortical or subcortical strokes.
    • Stroke incidence varied by brain region, with the largest volumes in the ACA distribution.

    Conclusions:

    • Middle cerebral artery and anterior cerebral artery strokes occurred most frequently and may be suitable for long-term studies due to less severe initial symptoms.
    • Neurologic symptoms are not always reliable indicators of stroke occurrence or severity.
    • Further refinement, potentially using imaging endpoints, is needed for this rabbit stroke model.