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Updated: Jun 13, 2026
07:18
Bone Conditioned Medium: Preparation and Bioassay
Published on: July 8, 2015
A clinical study on bone formation using a demineralized bone matrix and resorbable membrane
Young-Kyun Kim1, Su-Gwan Kim, Sung-Chul Lim
1Department of Oral and Maxillofacial Surgery, Section of Dentistry, Seoul National University Bundang Hospital, Seongnam City, Republic of Korea.
Summary
Guided bone regeneration (GBR) using Orthoblast II and Ossix membranes promoted significant new bone formation. This bone grafting technique demonstrated increasing bone remodeling and maturity over a 6-month healing period.
Area of Science:
- Dental Implantology
- Periodontology
- Biomaterials Science
Background:
- Guided bone regeneration (GBR) is crucial for bone defect repair around implants.
- Evaluating novel biomaterials for GBR is essential for improving clinical outcomes.
- Dehiscence defects often require bone grafting for successful implant integration.
Purpose of the Study:
- To assess new bone formation after GBR using a specific composite material.
- To evaluate the efficacy of Orthoblast II and Ossix membranes in bone regeneration.
- To analyze bone remodeling and graft resorption over time.
Main Methods:
- A prospective study involving 14 patients requiring bone grafting for dehiscence defects.
- Biopsy specimens were obtained after 4- and/or 6-month healing periods.
- Histomorphometric analysis was performed using a computer-assisted imaging system.
Main Results:
- Significant new bone formation (12.3%-78.7%) was observed.
- Bone formation and remodeling increased with healing time.
- Grafted materials showed partial resorption with evidence of ongoing bone maturation.
Conclusions:
- GBR with Orthoblast II and Ossix membranes supports favorable bone formation.
- Increasing woven bone to lamellar bone ratios indicate progressive bone remodeling.
- The study provides evidence for continuous resorption of grafting materials and bone maturation.
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01:40Bone Remodeling
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01:18The Bone Matrix
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