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Related Concept Videos

Bipolar Disorder01:30

Bipolar Disorder

Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.

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Related Experiment Video

Updated: Jun 13, 2026

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies
05:22

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

Preattentive dysfunction in bipolar disorder: a MEG study using auditory mismatch negativity.

Yuichi Takei1, Sumie Kumano, Yoko Maki

  • 1Department of Psychiatry and Human Behavior, Gunma University Graduate School of Medicine, Japan.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|April 27, 2010
PubMed
Summary

Preattentive information processing is impaired in bipolar disorder, shown by delayed mismatch negativity (MMNm) magnetic field power. This dysfunction occurs regardless of clinical symptoms and is distinct from sensory processing deficits.

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Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
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Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Published on: October 24, 2012

Related Experiment Videos

Last Updated: Jun 13, 2026

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies
05:22

Dissociation of the Confounding Influences of Expectancy and Integrative Difficulty Residing in Anomalous Sentences in Event-related Potential Studies

Published on: May 9, 2019

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
08:45

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Published on: October 24, 2012

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Psychiatry

Background:

  • Cognitive dysfunction is a key feature of bipolar disorder (BD).
  • Electrophysiological examination of information processing deficits in BD is limited.
  • This study investigates preattentive and sensory information processing using magnetoencephalography (MEG).

Purpose of the Study:

  • To examine preattentive auditory information processing in bipolar disorder using mismatch field (MMNm) components.
  • To assess sensory information processing using P1m components via MEG.
  • To correlate electrophysiological findings with clinical symptoms in bipolar disorder.

Main Methods:

  • Ten patients with bipolar disorder and 20 healthy volunteers underwent MEG.
  • Auditory stimuli (standard and deviant tones/vowels) were presented.
  • MMNm and P1m components were analyzed in response to auditory changes.

Main Results:

  • MMNm magnetic global field power in the right hemisphere was significantly delayed in bipolar disorder patients.
  • P1m components did not differ between patients and controls.
  • MMNm dipole location in the left hemisphere was inferior in bipolar disorder patients, unrelated to clinical symptoms.

Conclusions:

  • Preattentive information processing is impaired in bipolar disorder, independent of clinical presentation.
  • This preattentive dysfunction is not attributable to sensory-level deficits.
  • MMNm latency and power differences suggest a distinct preattentive processing impairment in bipolar disorder compared to major depressive disorder.