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Temporal correlation between transcriptional changes and increased synthesis of hyaluronan in experimental cardiac

Urban Hellman1, Stellan Mörner, Anna Engström-Laurent

  • 1Department of Public Health and Clinical Medicine/Medicine, Umeå University, Sweden. urban.hellman@medbio.umu.se

Genomics
|April 27, 2010
PubMed

Insights

Hyaluronan synthesis and gene expression in cardiac hypertrophy are coordinated. Angiotensin II may mediate this process through immediate early genes, impacting cardiac growth.

Area of Science:

  • Cardiovascular Biology
  • Molecular Cardiology
  • Biochemistry

Background:

  • Hyaluronan (HA) levels increase in cardiac hypertrophy.
  • The role of HA synthesis regulation in cardiac growth is not fully understood.

Purpose of the Study:

  • To investigate the regulation of hyaluronan synthesis in cardiac hypertrophy.
  • To correlate myocardial hyaluronan concentration with gene transcription over time.

Main Methods:

  • Quantitative measurement of myocardial hyaluronan.
  • Gene transcription analysis in hypertrophic cardiac tissue.
  • Factor analysis to study correlations over time.

Main Results:

  • A subset of differentially expressed genes correlated with increased hyaluronan synthesis.
  • Up-regulation of transcription factors Myc, Fos, Junb, and Egr1.
  • Up-regulation of the Ace gene, indicating increased angiotensin II levels.

Conclusions:

  • Coordinated synthesis of hyaluronan and pro-hypertrophic gene expression occurs in cardiac hypertrophy.
  • Immediate early genes likely regulate this coordinated process.
  • Angiotensin II is a potential mediator of hyaluronan synthesis and gene expression in cardiac hypertrophy.

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