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Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
Published on: March 10, 2020
Maternal use of bupropion and risk for congenital heart defects
Sura Alwan1, Jennita Reefhuis, Lorenzo D Botto
1Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
Objective:
We sought to determine if maternal bupropion treatment in early pregnancy is associated with congenital heart defects in the infant.
Study Design:
We conducted a retrospective case-control study of birth defects risk factors. Data on 6853 infants with major heart defects were compared with 5869 control infants born in 1997-2004. Bupropion exposure was defined as any reported use between 1 month before and 3 months after conception.
Results:
Mothers of infants with left outflow tract heart defects were more likely to have reported taking bupropion than mothers of control infants (adjusted odds ratio, 2.6; 95% confidence interval, 1.2-5.7; P = .01).
Conclusion:
We identified a positive association between early pregnancy bupropion use and left outflow tract heart defects; however, the magnitude of the observed increased risk was small. Nevertheless, further studies are needed to confirm these results.
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