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Urinary chromium loss associated with diabetes is offset by increases in absorption
Nicholas R Rhodes1, DeAna McAdory, Sharifa Love
1Department of Chemistry, The University of Alabama, Tuscaloosa, AL 35487, USA.
Journal of Inorganic Biochemistry
|April 27, 2010
Summary
Diabetic rats show increased urinary chromium loss, but this is balanced by higher absorption. Supplementing chromium is unlikely to help, as benefits from high doses are pharmacological, not due to deficiency.
Area of Science:
- Nutritional Science
- Metabolic Disorders
- Trace Element Metabolism
Background:
- Diabetes and insulin resistance are associated with altered chromium metabolism.
- Understanding chromium (Cr) transport and excretion is crucial for metabolic health.
Purpose of the Study:
- To investigate chromium (Cr) handling in diabetic and insulin-resistant rats.
- To determine if chromium supplementation is beneficial in these conditions.
Main Methods:
- Comparison of urinary Cr loss and absorption rates in diabetic, obese insulin-resistant, and lean rats.
- Analysis of Cr transport and distribution.
Main Results:
- Diabetic rats exhibit increased urinary Cr loss, counterbalanced by enhanced Cr absorption.
- Insulin-resistant rats show altered Cr transport but similar urinary loss and absorption compared to lean rats.
- Dietary chromium is sufficient to meet increased absorption needs in diabetes.
Conclusions:
- Increased urinary chromium loss in diabetes and insulin resistance is compensated by increased absorption.
- Nutritional chromium supplementation is unlikely to be beneficial as deficiency is not the cause of metabolic alterations.
- Observed benefits of high-dose chromium (Cr(III)) complexes are likely due to pharmacological effects, not correcting a deficiency.
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