Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Malaria01:29

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...
Symbiosis00:58

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ecological similarity governs non-native fish establishment while human pressure and native diversity shape invasion richness.

Science advances·2025
Same author

Did Implementation of Michigan Surgical Quality Collaborative Initiative Reduce the Post-Operative Infection Rate Elective Colorectal Surgery? A Community Hospital Experience.

The American surgeon·2024
Same author

Severe falciparum malaria in pregnancy in Southeast Asia: a multi-centre retrospective cohort study.

BMC medicine·2023
Same author

Severe Hemolysis during Primaquine Radical Cure of Plasmodium vivax Malaria: Two Systematic Reviews and Individual Patient Data Descriptive Analyses.

The American journal of tropical medicine and hygiene·2023
Same author

Born too soon in a resource-limited setting: A 10-year mixed methods review of a special care baby unit for refugees and migrants on the Myanmar-Thailand border.

Frontiers in public health·2023
Same author

An open dataset of <i>Plasmodium vivax</i> genome variation in 1,895 worldwide samples.

Wellcome open research·2022

Related Experiment Video

Updated: Jun 13, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
10:22

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Malaria in children.

Jane Crawley1, Cindy Chu, George Mtove

  • 1Medical Research Council Clinical Trials Unit, London, UK.

Lancet (London, England)
|April 27, 2010
PubMed
Summary

Global malaria control efforts show progress, but drug and insecticide resistance, alongside challenges with Plasmodium vivax, threaten gains. New interventions and vaccines are crucial for malaria elimination, especially in children.

Area of Science:

  • Global health
  • Infectious diseases
  • Parasitology

Background:

  • Significant political and financial investment in malaria control over the past decade.
  • Increasing coverage of vector control and artemisinin-based combination therapy (ACTs).
  • Declining childhood morbidity and mortality from Plasmodium falciparum malaria in some regions, fueling interest in elimination.

Purpose of the Study:

  • To review current knowledge and controversies in pediatric malaria management.
  • To highlight challenges and future directions for malaria control and elimination.
  • To provide guidance for clinicians managing malaria in children, particularly in resource-limited settings.

Main Methods:

  • Review of existing literature and expert consensus on malaria epidemiology, pathophysiology, diagnosis, treatment, and prevention.

More Related Videos

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes
08:20

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

Related Experiment Videos

Last Updated: Jun 13, 2026

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
10:22

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging
09:04

In Vivo Tracking of Edema Development and Microvascular Pathology in a Model of Experimental Cerebral Malaria Using Magnetic Resonance Imaging

Published on: June 8, 2017

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes
08:20

In Vitro Assay of Plasmodium-Infected Red Blood Cell Killing by Cytotoxic Lymphocytes

Published on: August 17, 2022

  • Discussion of current challenges including drug resistance, insecticide resistance, and Plasmodium vivax elimination.
  • Focus on pediatric malaria, considering specific vulnerabilities and management strategies.

    • Main Results:

    • Progress in malaria control is threatened by parasite resistance to antimalarial drugs and vector resistance to insecticides.
    • Plasmodium vivax presents unique elimination challenges due to its dormant liver stage.
    • Access to effective, affordable community-level treatment remains a significant hurdle.

    Conclusions:

    • Urgent need for new antimalarial drugs and insecticides to combat resistance.
    • Development and implementation of an effective malaria vaccine remain critical goals.
    • Effective malaria elimination strategies must address Plasmodium vivax and ensure equitable access to treatment for children.