Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 13, 2026

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting
10:36

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Published on: December 9, 2022

Cell-laden microengineered gelatin methacrylate hydrogels.

Jason W Nichol1, Sandeep T Koshy, Hojae Bae

  • 1Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.

Biomaterials
|April 27, 2010
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In situ three-dimensional printing for reparative and regenerative therapy.

Biomedical microdevices·2019
Same author

A Perspective on 3D Bioprinting in Tissue Regeneration.

Bio-design and manufacturing·2019
Same author

Sutureless repair of corneal injuries using naturally derived bioadhesive hydrogels.

Science advances·2019
Same author

Hierarchically Patterned Polydopamine-Containing Membranes for Periodontal Tissue Engineering.

ACS nano·2019
Same author

A Microfabricated Sandwiching Assay for Nanoliter and High-Throughput Biomarker Screening.

Small (Weinheim an der Bergstrasse, Germany)·2019
Same author

A simple layer-stacking technique to generate biomolecular and mechanical gradients in photocrosslinkable hydrogels.

Biofabrication·2019
Same journal

Oral colon-targeted micro-nano formulation engineered in microfluid for synergistic therapy of inflammatory bowel disease.

Biomaterials·2026
Same journal

Manganese@Gold cluster-coordinated covalent organic frameworks-based artificial metalloenzymes with cascade biocatalysis and amplified systemic stimulation to combat malignant tumor metastasis.

Biomaterials·2026
Same journal

Remodeling TME via feedback-driven photothermal-ferroptosis-immune cascade.

Biomaterials·2026
Same journal

Corrigendum to "Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib" [Biomaterials 2020, 240, 119845].

Biomaterials·2026
Same journal

Mg-integrated octopus-inspired hydrogel dressing enables autonomous adhesion and wound closure for enhanced healing via sequential microenvironment regulation.

Biomaterials·2026
Same journal

Engineering miRNA-223 nanocomplexes via bioorthogonal self-assembly for precision therapy of intervertebral disc degeneration.

Biomaterials·2026
See all related articles

Gelatin methacrylate (GelMA) hydrogels offer a cell-responsive, tunable, and inexpensive platform for microengineered tissues. This material enables high-fidelity patterning for creating functional microtissues and microfluidic devices.

Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Microfluidics

Background:

  • The cellular microenvironment is crucial for microengineered tissue function.
  • Photopatterning offers high pattern fidelity but often lacks cell responsiveness and biodegradability in hydrogels.
  • Existing photopolymerizable hydrogels have limitations in cell interaction and degradation.

Purpose of the Study:

  • To demonstrate gelatin methacrylate (GelMA) as a versatile, cell-responsive hydrogel for microengineered tissues.
  • To evaluate GelMA's properties for fabricating microtissues and microfluidic devices.
  • To explore GelMA's tunability for diverse applications.

Main Methods:

  • Photopatterning of cell-laden hydrogels using GelMA.
  • Assessment of cell behavior (adhesion, proliferation, migration) on and within GelMA.

More Related Videos

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
09:37

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering

Published on: October 26, 2009

Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks
10:25

Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks

Published on: December 21, 2019

Related Experiment Videos

Last Updated: Jun 13, 2026

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting
10:36

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Published on: December 9, 2022

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering
09:37

Cellular Encapsulation in 3D Hydrogels for Tissue Engineering

Published on: October 26, 2009

Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks
10:25

Protocols of 3D Bioprinting of Gelatin Methacryloyl Hydrogel Based Bioinks

Published on: December 21, 2019

  • Tuning of GelMA properties (hydration, mechanical) via methacrylation degree and concentration.
  • Fabrication of microfluidic channels and cellular micropatterns using GelMA.

    • Main Results:

    • GelMA supported cell adhesion, proliferation, elongation, and migration.
    • GelMA properties were tunable by adjusting methacrylation degree and gel concentration.
    • High pattern fidelity and resolution were achieved with GelMA photopatterning.
    • Perfusable microfluidic channels and cellular micropatterns were successfully fabricated.

    Conclusions:

    • GelMA is an inexpensive, cell-responsive hydrogel suitable for microengineered tissues.
    • GelMA enables the creation of complex cell-responsive microtissues and microfluidic devices.
    • GelMA offers a promising platform for applications requiring tunable, cell-interactive hydrogels.