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Related Concept Videos

Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
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The normal cardiac rhythm is a synchronized electrical activity that facilitates the regular and coordinated contraction of the heart muscle. This process is essential for efficient blood circulation throughout the body. The fundamental elements involved in establishing and maintaining this rhythm include the unique electrical properties of cardiac muscle cells, the sinoatrial (SA) node's pacemaker function, the specialized conducting system, and the ionic mechanisms underlying each phase of...
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Related Experiment Video

Updated: Jun 13, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

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Published on: December 11, 2017

Recoordination rather than resynchronization predicts reverse remodeling after cardiac resynchronization therapy.

Chun-Li Wang1, Chia-Tung Wu, Yung-Hsin Yeh

  • 1First Division of Cardiovascular Department, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.

Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography
|April 27, 2010
PubMed
Summary

Acute recoordination, measured by radial discoordination index (RDI) reduction after cardiac resynchronization therapy (CRT), effectively predicts CRT response. This acute phenomenon is a superior predictor of left ventricular reverse remodeling compared to resynchronization alone.

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Area of Science:

  • Cardiology
  • Medical Imaging
  • Heart Failure Management

Background:

  • Mechanical discoordination via MRI predicts left ventricular (LV) reverse remodeling post-cardiac resynchronization therapy (CRT) better than dyssynchrony.
  • Assessing acute recoordination via speckle-tracking echocardiography offers a novel approach to predict CRT response.

Purpose of the Study:

  • To evaluate the predictive value of acute recoordination for CRT response.
  • To compare acute recoordination with acute resynchronization in predicting CRT success.

Main Methods:

  • Thirty heart failure patients undergoing CRT were studied at baseline, immediately post-CRT, and at 6-month follow-up.
  • Acute recoordination was indexed by the reduction in radial discoordination index (RDI) post-CRT.
  • CRT responders were defined by a >15% decrease in LV end-systolic volume at 6 months.

Main Results:

  • Responders showed a significant, sustained reduction in RDI immediately after CRT and at 6 months (P < .001).
  • Non-responders did not exhibit significant RDI changes.
  • Acute recoordination strongly correlated with LV reverse remodeling (r = 0.75, P < .001), outperforming acute resynchronization (r = 0.43, P = .02).

Conclusions:

  • Acute recoordination is a superior predictor of CRT response compared to resynchronization, baseline dyssynchrony, or discoordination.
  • LV recoordination post-CRT is an acute event that accurately forecasts long-term CRT response.