Related Experiment Video

Updated: Jun 13, 2026

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

[Renal cell carcinoma management and therapies in 2010]

B Albouy1, M Gross Goupil, B Escudier

  • 1Institut Gustave-Roussy, Département de médecine, 39, rue Camille-Desmoulins, 94805 Villejuif, France.

Bulletin Du Cancer
|April 27, 2010
PubMed

Insights

Targeted therapies have revolutionized advanced renal cell carcinoma (RCC) treatment, improving survival. Current options include cytokines, antiangiogenic drugs, and mTOR inhibitors, with ongoing trials for adjuvant settings.

Area of Science:

  • Oncology
  • Molecular Biology
  • Translational Medicine

Background:

  • Advanced renal cell carcinoma (RCC) presents a poor prognosis and resistance to traditional chemotherapy.
  • Recent advancements in understanding RCC molecular biology and pathogenesis have spurred novel therapeutic developments.

Purpose of the Study:

  • To review the impact of targeted molecular therapies on the management of metastatic RCC.
  • To summarize approved therapies and ongoing research in advanced RCC treatment.

Main Methods:

  • Review of randomized phase III clinical trials.
  • Analysis of approved targeted therapies including cytokines, antiangiogenic agents, and mTOR inhibitors.
  • Discussion of the role of nephrectomy in multimodality treatment.

Main Results:

  • Targeted therapies against VEGF-VEGFR and mTOR have significantly improved overall survival and progression-free survival in advanced RCC.
  • Six molecules are currently approved for advanced RCC: cytokines (IL-2, IFN), antiangiogenic therapies (sunitinib, sorafenib, bevacizumab), and mTOR inhibitors (Temsirolimus, everolimus).
  • Nephrectomy remains a key component of treatment, with ongoing trials evaluating its role alongside antiangiogenic therapies.

Conclusions:

  • The management of metastatic RCC has been transformed by targeted molecular therapies.
  • Further research is evaluating these novel therapies in the adjuvant setting and the role of nephrectomy.

More Related Videos

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma06:39

Technical Modification of the Terminal Ureter During Total Transperitoneal Laparoscopic Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

Published on: November 22, 2019

Related Concept Videos

Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Urinary Tract Calculi V: Nursing Management01:28

Urinary Tract Calculi V: Nursing Management

AssessmentSubjective Data: Obtain a detailed health history, including any recent or chronic urinary tract infections, periods of immobilization, previous episodes of renal calculi, and medical conditions such as gout, benign prostatic hyperplasia, or hyperparathyroidism. Review the medication history for drugs that may influence stone formation, including allopurinol, analgesics, loop diuretics, or thiazide diuretics. Document the use of long-term indwelling catheters and any past surgical...