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Chronic sleep deprivation markedly reduces coagulation factor VII expression
Mirko Pinotti1, Cristiano Bertolucci, Elena Frigato
1Neuroscience Institute, Morehouse School of Medicine, 720 Westview Dr, Atlanta, GA 30310, USA.
Haematologica
|April 27, 2010
Summary
Chronic sleep loss reduces thrombin generation by decreasing factor VII (FVII) levels, impacting blood coagulation. This effect is reversible upon restoring normal sleep patterns.
Area of Science:
- Biomedical Science
- Hematology
- Sleep Medicine
Background:
- Chronic sleep loss is prevalent in industrialized nations and linked to cardiovascular disorders.
- Coagulation parameter variations may mediate the relationship between sleep loss and cardiovascular issues.
Purpose of the Study:
- To investigate the impact of partial sleep deprivation on thrombin generation and coagulation factors.
- To determine if sleep deprivation influences the extrinsic (TF/FVIIa) and intrinsic coagulation pathways.
Main Methods:
- Utilized a mouse model with a specific protocol for partial sleep deprivation (seven days).
- Assessed thrombin generation potential in plasma via extrinsic and intrinsic activation.
- Measured plasma activity levels and liver mRNA levels of coagulation factor VII (FVII).
Main Results:
- Partial sleep deprivation significantly decreased thrombin generation potential by 30.5% via extrinsic activation.
- Plasma activity of factor VII (FVII) decreased by 49.8%, with a more pronounced reduction (85.7%) at the liver mRNA level.
- Three days of recovery sleep fully restored thrombin generation and FVII activity.
Conclusions:
- Chronic sleep deprivation reversibly reduces FVII expression levels.
- Sleep deprivation influences the efficiency of the TF/FVIIa activation pathway.
- This study demonstrates a direct link between sleep loss and altered coagulation dynamics.
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