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Related Experiment Video

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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

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Published on: May 31, 2016

Fatigue, function, and mortality in older adults.

Elior Moreh¹, Jeremy M Jacobs, Jochanan Stessman

¹Department of Geriatrics and Rehabilitation, Hadassah-Hebrew University Medical Center, Mt Scopus, P.O. Box 24035, Jerusalem 91240, Israel.

The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences

|April 27, 2010

Summary

Fatigue significantly impacts older adults

Area of Science:

Gerontology
Epidemiology
Public Health

Background:

Fatigue is prevalent in older adults, but its long-term effects on health, function, and mortality are not well understood.
This study investigates the association between fatigue and health outcomes in the elderly over an extended period.

Purpose of the Study:

To evaluate the relationship between fatigue and health status, functional capacity, and mortality in individuals aged 70-88 years.
To explore the predictive value of fatigue on subsequent health and functional decline.

Main Methods:

A representative community-dwelling cohort (born 1920-1921) from the Jerusalem Longitudinal Study (1990-2008) was assessed.
Mortality data and health/functional status were evaluated at ages 70, 78, and 85.

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Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

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Main Results:

Fatigue prevalence increased with age (29% at 70, 53% at 78, 68% at 85), higher in women.
Fatigue was linked to poorer health, function, and psychosocial factors, predicting declines in self-rated health, daily activities, physical activity, and sleep.
Fatigue at age 70 predicted subsequent depression, and hazard ratios for mortality were significant, though reduced by physical activity and depression levels.

Conclusions:

Fatigue in the elderly, including the oldest old, negatively affects health, function, and mortality.
The impact of fatigue on mortality may be mediated by its complex relationship with depression and physical activity levels.