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Asymptomatic cerebral calcification--a previously unrecognized feature.

M M Arnold1, L Kreel

  • 1Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, Chinese University of Hong Kong.

Postgraduate Medical Journal
|February 1, 1991
PubMed
Summary
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Cortical-pia mater calcification, a newly identified finding, was detected in autopsy brains. This calcification may indicate the cause of idiopathic epilepsies in older adults.

Area of Science:

  • Neuropathology
  • Radiology
  • Neuroscience

Background:

  • Globus pallidus calcification investigation revealed previously undocumented cortical-pia mater calcification.
  • No prior literature existed on this specific calcification in radiology, neurology, or neuropathology.

Purpose of the Study:

  • To determine the incidence and clinical significance of cortical-pia mater calcification.
  • To characterize the radiological and histological features of this calcification.

Main Methods:

  • Studied 20 consecutive autopsy brains (15 male, 5 female, age 32-73) using high-resolution radiography and histology.
  • Reviewed clinical records, autopsy findings, and available in-life neuroimaging (skull films, CT scans).

Main Results:

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  • Radiologically, calcifications appeared as 1-2 mm spots in the pia mater and subcortical regions of multiple lobes.
  • Histologically, calcifications were extracellular amorphous masses in necrotic neural tissue, associated with hemorrhage and hypoxic changes.
  • Occurrence was not age-related; temporal lobe calcification was common but asymptomatic.

Conclusions:

  • Cortical-pia mater calcification is a distinct pathological finding with a notable incidence in autopsy brains.
  • The high incidence in temporal lobes suggests it may be a marker for idiopathic epilepsies in the elderly.
  • Further research is needed to fully elucidate its clinical significance and etiological role.