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Related Experiment Video

Updated: Jun 13, 2026

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis

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Published on: June 24, 2018

Hypophosphataemic rickets/osteomalacia: a descriptive analysis.

S K Bhadada¹, A Bhansali, V Upreti

¹Departments of Endocrinology & Histopathology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.

The Indian Journal of Medical Research

|April 27, 2010

Summary

Hypophosphatemic rickets/osteomalacia (HRO) is a rare bone disorder. Treatment with phosphate, calcium, and vitamin D supplements improved patient well-being and biochemical markers.

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Area of Science:

Endocrinology
Metabolic Bone Diseases
Pediatric Endocrinology

Background:

Hypophosphatemic rickets/osteomalacia (HRO) is an uncommon metabolic bone disorder affecting all ages.
It is characterized by low serum phosphate levels, impairing bone mineralization.
The aetiology of HRO is variable.

Purpose of the Study:

To present the clinical profile of 17 patients with HRO.
To analyze the treatment outcomes for HRO in a tertiary care setting.
To identify key presenting features and diagnostic indicators for HRO.

Main Methods:

A retrospective analysis of 17 consecutive HRO patients (January 2000 - December 2006).
Data collected included aetiology, clinical, biochemical, and radiographic features.
Treatment protocols and patient outcomes were systematically evaluated.

Main Results:

HRO was more prevalent in females (70.5%) with a 35.3% family history.
Common symptoms included short stature, backache, bony deformities, and joint pain.
Treatment with phosphate, calcium, and vitamin D supplements led to significant biochemical improvements (P<0.005 for phosphate, P<0.05 for alkaline phosphatase) and symptomatic well-being.

Conclusions:

HRO diagnosis should be considered in patients with short stature, deformities, or musculoskeletal pain, accompanied by low serum phosphate.
Normal intact parathyroid hormone (iPTH) and 25-hydroxy vitamin D levels are important diagnostic considerations.
Early diagnosis and appropriate treatment are crucial for managing HRO.