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Updated: Jun 13, 2026

Chromosome Preparation From Cultured Cells
Published on: January 28, 2014
Multiple unrelated chromosomal abnormalities in host cells after cord blood transplantation
HeeWon Moon1, JinHee Cho, Mina Hur
1Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
Summary:
We experienced a 16-year-old patient with T-cell acute lymphoblastic leukemia, who had multiple unrelated chromosomal abnormalities in host cells after chemotherapy and cord blood transplantation (CBT). In 7 consecutive cytogenetic studies after CBT, he showed various chromosomal abnormalities including t(1;11)(p32;q23), t(8;21)(q22.2;q22.2), t(6;10)(p21.3;q26), and del(7) (q22q34). His chromosomal abnormalities were unstable and different in each cytogenetic study except del(7)(q22q34). He had neither anemia nor leukopenia, and his thrombocytopenia continuously improved after CBT. He was clinically stable for 2.5 years despite his complex chromosomal abnormalities. The clinical relevance of genetic instabilities in host cells after CBT is unclear, and long-term monitoring with additional cases is needed.
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