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Updated: Jun 13, 2026

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

Dengue viral infections.

Padmalal Gurugama¹, Pankaj Garg, Jennifer Perera

¹Colombo South Teaching Hospital, Sri Lanka.

Indian Journal of Dermatology

|April 27, 2010

Summary

This summary is machine-generated.

Dengue is a major mosquito-borne viral disease affecting 112 countries, causing millions of cases globally. This review covers dengue epidemiology, clinical features, and management strategies to reduce its significant public health impact.

Keywords:

Dengue clinical features epidemiology treatment

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Area of Science:

Medical Entomology
Virology
Epidemiology

Background:

Dengue viral infections represent a critical global public health challenge, endemic in 112 countries.
An estimated 100 million dengue fever and 500,000 dengue hemorrhagic fever (DHF) cases occur annually worldwide.
DHF disproportionately affects children under 15, particularly in South and Southeast Asia.

Purpose of the Study:

To provide a comprehensive overview of dengue infections.
To detail the epidemiology, clinical manifestations, and pathophysiologic mechanisms.
To discuss current management, control strategies, and vaccine development efforts.

Main Methods:

This review synthesizes existing literature on dengue.
It examines epidemiological data, clinical presentations, and host responses.
Pathophysiologic mechanisms, vector breeding, and control measures are analyzed.

Main Results:

Dengue presents with diverse symptoms, ranging from asymptomatic infection to severe dengue hemorrhagic fever.
Delayed recognition and treatment contribute to high morbidity and mortality.
Viral structure, host response, serotypes, and vector conditions influence disease spread and severity.

Conclusions:

Effective dengue management requires early diagnosis and prompt supportive care.
Integrated vector control and ongoing vaccine research are crucial for disease prevention.
Understanding dengue's complex epidemiology and clinical spectrum is vital for global health initiatives.