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Updated: Jun 13, 2026
08:56
Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
Polyuria, acidosis, and coma following massive ibuprofen ingestion
Michael Levine1, Amandeep Khurana, Anne-Michelle Ruha
1Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ, USA. Michael.Levine@bannerhealth.com
Summary
A massive ibuprofen overdose, despite extremely high serum levels, was survived by a young man. This case highlights the potential for recovery with aggressive supportive care, even in severe nonsteroidal anti-inflammatory drug toxicity.
Area of Science:
- Pharmacology
- Toxicology
- Emergency Medicine
Background:
- Ibuprofen is a common over-the-counter nonsteroidal anti-inflammatory drug (NSAID).
- Significant toxicity from ibuprofen overdose is rare.
- Massive ingestions can lead to severe clinical manifestations.
Observation:
- A 19-year-old man ingested 90g of ibuprofen.
- He presented with deteriorating consciousness, lactic acidosis, and polyuria.
- Serum ibuprofen levels reached 739.2 mg/L, significantly exceeding previous fatal case concentrations.
Findings:
- The patient survived the massive ibuprofen overdose.
- Unique presentation included profound polyuria and metabolic acidosis.
- High ibuprofen levels were documented despite a favorable outcome.
Implications:
- Aggressive supportive care is crucial in managing massive NSAID overdoses.
- Polyuria is an under-recognized symptom in severe ibuprofen toxicity.
- This case expands the understanding of ibuprofen's toxicological profile and survival limits.
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